The Beast’s Unholy Trinity of Technology; Transhumanism – Genetic Editing – Artificial Intelligence. ‘Birds of a Feather’, Genetic Edit Together; BREAKING NEWS; The Kingdom’s bln dollar-a-year project to extend healthy lifespan. Exclusive: Saudi’s Crown Prince heads new bln-dollar foundation to ‘decelerate aging.’ (5) Created by Saudi Royal Order. ‘Gene (5) Editing Clinics in NEOM BABYLON.’

The non-profit organization Hevolution Foundation – overseen by Saudi Arabia’s Crown Prince Mohammed bin Salman – aims to find and invest in innovative ways to “decelerate” the aging process and extend the number of years people live in good health.

Jennifer Bell, Al Arabiya English Published: 28 September ,2023: 07:17 AM GSTUpdated: 28 September ,2023: 07:13 PM GST

Four years ago, by royal decree, Saudi Arabia’s Crown Prince Mohammed bin Salman pledged a vast financial investment – over a billion dollars a year – into research that would extend the healthy human lifespan, which led to the birth of the Kingdom’s Hevolution Foundation.

The Foundation – a global fund that aims to find and invest in innovative ways to “decelerate” the aging process and extend the number of years people live in good health – is heavily invested in academic research and biotech startups that promote longevity by slowing aging and combating age-related diseases.

In an interview with Al Arabiya English, Saudi Princess HRH Dr Haya Bint Khaled Bin Bandar al-Saud, Vice President of Organizational Strategy & Development, said she believes the Foundation’s work will see tangible results in decelerating aging in a matter of years.

“We are an organization that’s helping all humanity,” she said, adding that the initiative aims to be the first non-profit to pursue age-related therapeutic breakthroughs. It is committed to funding global scientific discovery, and investing in private companies and entrepreneurs dedicated to advancing aging science. “Hevolution wants to become a convener and to become a catalyst in the field and bridge the gap in the funding in terms of investment and in science, and the Hevolution Foundation has done multiple activities in the past year to ensure that we develop this convening and catalyst platform to move the healthspan science forward for the benefit of all of humanity.”Dr al-Saud said therapeutics that extend a healthy human lifespan will redefine healthcare in the 21st century.

As of 2023, the non-profit organization has expanded outside the Kingdom’s borders – which houses its Riyadh headquarters – into its first international hub in Boston, Massachusetts. The US office makes it the country’s biggest hub for life sciences. It is eying up a further global hub in the United Kingdom by the end of the year and has plans for an Asia hub. It has also, in the past 18 months, pledged $200 million for research into anti-aging, longevity biotech and healthy lifespan, a planned investment in two biotech companies, evaluated more than 150 companies across the globe as it eyes funding opportunities, is whittling down more than 500 (5) grant applications from scientists around the world, has published the GCC’s first roadmap in healthy human lifespan, and is gearing to host the Kingdom’s first Global Healthspan Summit in November.

The organization has funded numerous researchers at top-tier institutions, including via a partnership with the American Federation for Aging Research (AFAR), a leading non-profit organization supporting biomedical aging research.

The primary investment focus of the Hevolution Foundation is on early-stage companies developing therapies and technologies that target the root causes of aging. The Saudi-headquartered Foundation will also invest in platforms and technologies that aim to compress drug development timelines or increase accessibility to therapeutics within the context of extending the healthy human lifespan.

Also speaking with Al Arabiya English, Dr Mehmood Khan, CEO of the Hevolution Foundation, said the “genesis” of the Hevolution Foundation “was to take on a global health challenge which affects every person on the planet – everybody’s aging.” An increased life expectancy is accompanied by increasing disability and diseases that are associated with aging, said Dr Khan. “And nobody knows that better than the UK NHS, which essentially is crumbling as a result of the disease burden from age-related diseases. The same is true in the US. And as we look at the global challenge, China, Japan, South Korea, with aging populations and now much of the developing world as well, including the increasing prevalence of diabetes, cancer with the young population in the Middle East.”

Dr Khan points out that the average lifespan has grown dramatically since the mid-1800s. However, the average healthy lifespan (the years spent in good health) has hardly increased. Although people live longer, their additional years are usually accompanied by poor health. Most of this disease burden is attributable to age-related, non-communicable diseases (NCDs).

Moreover, many societies worldwide are steadily graying, and elderly populations are swelling (a phenomenon known as the age wave or the silver tsunami) even as birth rates are falling. Aging societies face a future in which older people will noticeably outnumber the working-age population, presenting an unprecedented economic challenge and possibly fueling intergenerational tension. This is already the case in some countries, such as Japan, where 30 percent of the population is 65 or older.

Even beyond public health challenges, population aging will usher in fundamental, society-wide changes needed to accommodate a transformed population structure. “This [anti-aging research] is one of the most under-invested fields relative to the need. So, we want to balance that out and get all the players up the table, including the private sector,” said Dr Khan. “So that’s sort of the genesis of Hevolution and its purpose, which is to expand healthy lifespan… and everything we invest in and fund and do has to be democratized, and we are really looking for things that are going to have an impact on as many people in the world as possible – regardless of their location, their gender, their age, and religion, etc.”

But why anti-aging?

With the Saudi Vision 2030, a strategic framework that seeks to diversify the Saudi Arabian economy, Dr Khan, who the Saudi royal family hired to oversee the global Foundation in 2020, said the Hevolution Foundation “perfectly aligns” with the goals of the Kingdom’s blueprint. He points out that AI and healthcare are at the heart of the 2030 framework. It seeks to boost the country’s image globally by investing in healthcare, education, artificial intelligence, and other projects.

Additionally, three priorities for the goal’s ongoing health reforms are to improve access to healthcare services, to improve the quality and efficiency of the health system, and to strengthen prevention against health threats, all of which are relevant to the healthy aging agenda. “Vision 2030 clearly lays out two things,” said Dr Khan. “One is the goal to extend the lifespan in the country. Yes, it also aims to prevent chronic diseases and improve the population’s health. When you combine those two parts of Vision 2030 you get the Hevolution Foundation.”

He added: “The consequence of aging is very relevant for the Middle East. Ask any Middle Eastern resident, and there are people who either have diabetes or know somebody who has a loved one who has diabetes, or heart disease.” “Now, in the region, one of the commonest cancers occurring is colon cancer (which) was almost unheard of two or three decades (ago).” “So, for all those reasons, this will need substantial investment. Based on our royal decree, we see ourselves as an opportunity to help lead this initiative for the world’s benefit. But it also is very relevant and maybe proportionate even more relevant to citizens of the GCC.”

Rapid expansion

The team – which began as a two-person band in 2019, with Dr al-Saud and Khan being the first two employees – has rapidly expanded in size, with 60 employees, a further 70 planned by the end of the year – and a team that proudly boasts half of its senior workforce as females – many of them Saudi, said Dr Khan. The US hub was the “obvious” choice for its first headquarters out of the Kingdom, Dr Khan said. “We looked at the global footprint of activity in life sciences in general on aging, sciences and aging biology, because our goal is not just to treat the diseases as an end stage – we’re not developing another diabetes drug – we’re trying to find out how do we change the aging process itself.” “Again, to emphasize, (it is) not so you can live longer, but that you live healthy for longer,” Dr Khan said.

“If you’re really going to have a launching pad for where you are moving this field, you have got to go where the action is. The US made clear sense. If we look at Boston, a combination of academic institutions, science activity, and venture capital in biotechnology companies as well as Big Pharma, there’s no question Boston has it all.” The UK – a “leader” in healthcare – was another obvious choice for its third headquarters to be opened next year, although the exact geographic location of the hub is yet to be determined.

The next step is Asia.

“Asia is rapidly growing, and we are a global entity. We look at where the activity will grow. Japan is continuing to grow in this area,” said Dr Khan. “South Korea, Singapore, China, etc. are also major players. Let us consider that 40 percent of Japan’s population is already 60. Almost half of China – with a one child policy – has a massive aging challenge. Same with Singapore. Meanwhile, South Korea’s fertility rate is the world’s lowest. So, the birth rate can’t even replace the current deaths in the population. So, you will have an aging population with very few young people. These are all major challenges.”

Dr Khan says, that far from just giving grants to fund research into extending the healthy lifespan, the idea of the Hevolution Foundation is to convene experts from fields from across the globe, who might not otherwise come together, to brainstorm and come up with innovative breakthroughs that can help with a myriad of age-related diseases – from diabetes, to cancer, to heart disease. “For example, we strike to bring together investors, scientists, Big Pharma, regulators, and policymakers at the same time. So, we are a convener. We are a catalyst, and we’re using multiple levers to say how do we catalyze to move forward faster.” “A lot of people are suffering from the consequences of aging-related diseases. And so, the faster we can move the field, the quicker we can bring solutions that are available to practitioners to healthcare providers to ultimately to consumers and patients. That is our mission.”

Delivering on its promise

The Hevolution Foundation is already delivering on that promise. “In our initial first year of operation, and by the end of this year, we will have funded scientists in more than two dozen laboratories around the world already,” said Dr Khan. “This year, we have pledged funding of more than $200 million in commitments that we’ve made with multiple institutions. We will also have funded a dozen scientists in the Kingdom of Saudi Arabia alone.”

Grants already support a wide range of research areas in longevity. For example, scientists are investigating how muscle stem cells and the neuromuscular junction change as people age. Researchers are also studying the cellular processes behind the onset of frailty in older individuals. Some scientists are exploring how RNA editing affects how our bodies respond to mitochondrial problems related to aging. Others are examining the age-related changes in the epigenetics of individual cells using a high-throughput approach. Research also focuses on understanding how the immune system linked to mitochondrial genes functions as the population ages.

Dr Khan added: “We have also evaluated more than 150 companies around the world. We’ve already built a database with the companies that are active in the aging space globally. And we’ve received applications and letters of intent from scientists from around the world. Over 500 scientists have applied one way or another to collaborate with the Fund and get funding from us in this field.” Dr al-Saud said another step forward for the Foundation’s work in 2023 has been drawing up the GCC’s first roadmap on healthy longevity and how to promote healthy aging in the Gulf, a region increasingly burdened by age-related diseases and conditions. This involved bringing the “best mindsets” across different sectors, ranging from science, policy, venture capitalists, investments, pharma – and the general public.

“We tried to address and understand what we observe today in terms of aging and accelerated aging by looking at the frequency of non-communicable diseases in the region. And we started the conversation on how we bridge the gap and address these challenges in the GCC and in the Kingdom of Saudi Arabia specifically.”

Saudi’s healthy lifespan

It led to the report, ‘Enabling a Healthy Lifespan for Saudi Arabia’, highlighting Saudi Arabia’s current advantageous demographic situation, with a predominantly working-age population and a low age-dependency ratio. However, this advantage will diminish as the workforce ages and birth rates decline. The report emphasizes the opportunity for Saudi Arabia to invest in healthy longevity now. Key topics covered in the report include trends in life expectancy, the gap between life expectancy and healthy life expectancy, non-communicable disease (NCD) risk factors, the aging transition in GCC countries, and strategies for addressing population aging challenges.

Saudi Arabia has seen significant improvements in average life expectancy, increasing from 46 to 76 years by 2020. However, healthy life expectancy is around 64 years, indicating a 10-year gap between lifespan and healthy years. Healthspan research aims to bridge this gap.

The United Nations’ Sustainable Development Goal 3 aims to reduce premature mortality from major NCDs by one-third globally by 2030. The report reveals that 30-year-old Saudis face a 20.9 percent probability of premature death from NCDs, higher than the global average. Diabetes prevalence in Saudi Arabia is 18.7 percent, with elevated blood pressure rates above 20 percent. Globally, the transition from an aging society to an aged society is accelerating. Saudi Arabia is projected to reach an aged society by 2042, with a 10-year transition period. Age-related NCDs strain healthcare systems and budgets, with diabetes alone accounting for 17.5 percent of Saudi Arabia’s health expenditures in 2015. NCDs also impact economic productivity through absenteeism and presenteeism. In the GCC, major NCDs cost $97.3 billion annually, equivalent to 3.4 percent of GDP in 2019. As the population ages, NCD burdens and costs will rise.

Promoting a healthy lifespan can unlock the “longevity dividend” by enabling individuals to contribute more to society over an extended period. Dr al-Saud said: “What we’re trying to achieve here, and it is alongside Vision 2030, is how do we decrease age and age-related diseases which we see in high frequency in the Saudi population.” “However, at the same time, we’re trying to extend lifespan, but putting these two things together, decreasing non-communicable diseases or age-related diseases and extending lifespan would eventually lead to extending healthy lifespan. So, we are working as Hevolution Foundation, trying to help in what’s happening in the Kingdom now in terms of the future, but at the same time, we’re also impacting externally in addressing this global challenge.”

Saudi’s financial commitment

While the hefty cost of the financial commitment that the Hevolution Foundation initially stated – SAR4 billion ($1.07 billion) has been widely talked about – Dr Khan said the goal is to leverage the investment of its funding to bring other agents and industries to the table to increase their investment. “So, we may be one of the larger players (now). However, if we end up being one of the smaller ones in a few years, we will celebrate,” said Dr Khan, adding this will demonstrate the Hevolution Foundation has helped spread the word about anti-aging and longevity funding and that much-needed investment into the under-funded field of longevity biotech has been stepped up. Regarding distributing grants, Dr Khan said a key interest is the several pathways that impact and regulate the aging process.

“Our ability to handle energy, our ability to get rid of debris in cells, our ability to restore our DNA function and things like that. We are looking at all of these. There are some promising areas in those areas within those that we are funding.” He said that they are also looking at measuring aging aptly. “There are two parts for measuring aging at a biological level. Look at your chronological age based on the year you were born. That’s one thing, but we all know that people age at different rates. Just go back to your high school pictures, and you look at your friends that you graduated high school with. Now look at them and some look young, some look older. So that tells you we act differently.”

But what is less talked about is that the body doesn’t age equally within the same person, said Dr Khan. “Some people’s heart age is faster than their brain. Some people – their brain is sharp, but their bodies age. And, by nature, bones might age at a different rate. Women now have aging in their bones faster. So, we know that aging is not uniform in a population. It’s not uniform, even in the same person.” “So, if we are going to move this field forward to start with, we need to determine how you measure somebody’s age. And then how you determine how fast their aging is. It’s one thing to tell you: I’m going to help you with slowing down your aging process. But it’s not one solution because it might be something that’s important to your heart, it might be something for my kidneys, etc.”

“We are going to look at how we work with scientists to get that right. It sounds so fundamental, but until you get that right, you’re not completely started to the sort of clinical trials that are needed to show that this is actually you can impact.” A roadblock now is that the field of longevity biotech “cannot absorb” the level of funding the Hevolution Foundation is willing to invest because the capacity, at present, is not there and needs to be built.

Building capacity, homegrown talent

As a solution, the Foundation is creating multiple programs in and outside the Kingdom to train new scientists, specifically in longevity and anti-aging. “We’ve created multiple programs that focus on training new scientists and inviting them to be introduced to aging science. And we are creating different fellowship programs, such as PhD programs, that will train postdocs to become aging scientists. We have also launched multiple grant programs locally and internationally.” “We are working on building the capacity and the capabilities of scientists in the field.” “We are ensuring that the rich knowledge transfer across centers of excellence across the globe in different geographical regions to the Kingdom, ensuring that we get proper training for Saudi scientists and attracting Saudi scientists in this field.”

“Obviously, we are a population that has a high frequency of non-communicable diseases, and we are a population that faces this challenge every single day. And introducing the aging field and ensuring that the Saudi population actually contributes towards solving this challenge is extremely important. We hope in the next couple of years we will have multiple scientists interested in the aging field, not only in Riyadh, but across the Kingdom.” Dr. Khan added that certain specialties – such as geroscientists – are in global demand, but there are critically few trained in the field.

“We want to change that. So, it’s not a case of, should we do this? There isn’t an alternative. We have to develop the training programs and capacity because it won’t be enough to say we borrow from outside. Because the outside – the UK, US, etc. – doesn’t have enough of their own. You have to develop homegrown talent to meet your own demands.” “By putting our headquarters in Riyadh, it gives us the opportunity to put a trained workforce and ecosystem right here in the Kingdom… it allows us to then contribute to this knowledge ecosystem for the life sciences in the academic sector, but also in this emerging new private sector of biotechnology, pharma, and life sciences.”

As Dr Khan pointed out, there are over one billion people over the age of 60. By 2050, that figure is set to rise to two billion. “Imagine if nothing changes? What will happen? What will happen to the UK’s NHS or the US health system? If twice the amount of people … needs to be taken care of?” “I see the Hevolution going forward with its mission,” said Dr al-Saud. “I can see numbers going down in terms of age and age-related diseases and seeing tangible outcomes across the globe and in the Kingdom. I know it’s a very difficult task. But our team – we call ourselves the Hevolutionaries – are here to address this challenge and deliver our mission.”

“This organization is actually helping all and all humanity, and I’m really looking forward to the future. We can deliver to all humanity.”

Saudi Arabia’s NEOM is Breeding a New City Built Around Genetic Engineering

Capital Frontiers

Cities for people or people for cities?

An unlikely marriage between city planning and gene modification is reinventing the future city. It’s also pushing the technological edge of gene modification as a tool for good – potentially as a natural outgrowth of the legacy of city planning as a tool for public health – and inspiring a debate around eugenics, one of humanity’s darkest obsessions.

When Saudi Arabia’s plans for NEOM were announced, readers around the globe were entranced with the city’s vision of glowing sand, an artificial moon, and flying cars that would render the traditional road-based framework of cities as we know them a thing of the past. Also curious were numerous allusions to the city as a hub for genetic research, gene modification, and fertilization technologies, along with language committing to the city as a place where public health would be optimized and diseases would be eliminated – the healthiest city in the world.

Whether a relationship exists between the city’s effort to reinvent the form of the contemporary metropolis – rethinking the utility of even the most basic conventions of the dogma that guides urban development today – and its broader effort to create a perfectly optimized city that will make people happier and healthier, and with better genes than ever before – requires creative thinking, but it is hardly a stretch. It also lends some thinking to the broader motivations of the $500 billion city being envisioned by the Crown of Saudi Arabia as the sparkling jewel that will propel the Kingdom’s efforts to reinvent itself for the 21st century.

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Much has been made of the vision for the city to grow tourism, education, economic opportunity, and wealth within the Kingdom. That it would also be a public health experiment in improving quality of life is an important part of the vision as well. After all, city planning has a long legacy of contributing to advancement of human health.

In fact, many of the very tenets of city planning dogma today are the product of such efforts over time: Philadelphia’s innovations in running water and public sewers, for instance, were borne from and key to eliminating the cholera epidemics that plagued American cities in the 19th century. Paris’ grand boulevards developed under Baron Haussman were envisioned with the goal of eliminating portions of the city where sunlight never fell that had long been festering grounds for rats that spread the plague. And the entire City Beautiful movement of the United States was borne from the shared innovations from the Athletics movement of the late 19th century, and workers’ rights movements of the same period, and the innovations of individuals like Sylvester Graham, who transformed the thinking about American diets at the time. The result was a push for cities with large breezy open spaces, healthier living quarters, less smog and soot from factories, and an ecosystem of accessible parks. They were also designed to improve mental health by creating a grounded city of hierarchical public amenities like churches and civic resources.

Contemporary cities have been under scrutiny from both sides for contributing to poor public health performance. Density advocates have long lobbied against the auto-orientation and heat island impacts of cities developed with a suburban orientation, which they assert are contributors to obesity, asthma, and malaise. Contemporary trends like transit-oriented development, bike lanes, and Vision Zero, for instance, are all designed to reduce vehicular travel, emissions, and make pedestrian movement safer.

On the other side, however, density opponents have pointed out that cities, even when developed densely, can still be terrible performers when it comes to mental health. A 2016 story in the Washington Post noted that for decades and decades the densest places make people unhappy, and in an age of technology coupled with a greater focus on mental health generally, the problem is only getting worse. Cities as they are built today, in short, are in crisis, as they are making people miserable and exacerbating a societal explosion in depression and technological fatigue

It stands to reason that the world is in need of a fundamental reinvention of cities as part of a broader societal strategy to addressing both physical AND mental health. Such a moment would be part of the natural evolution of cities, continuing on the great tradition of the Garden City and City Beautiful movements.

What’s interesting about NEOM, however, is that these innovations are being explored within the public health context of Saudi Arabia that is unique for the world, and that has given credence to exploring them not only as physical innovations, but as biological ones as well. The primary reason for this is that in addition to obesity as the product of a natural desert environment that discourages outdoor activity, Saudi Arabia is uniquely impacted by a wide range of genetically inherited diseases. Due to its extremely private cultural orientation which emphasizes close bonds with family and tribe over mingling and experimentation, Saudi Arabia has long bred marriages and relationships within tighter relatedness circles than other cultures. By some estimates 40 percent of Saudis are married to first cousins or first relatives.

Naturally, the closeness of such relationships has borne high rates of genetically inherited diseases. The incidence rates for most such diseases in Saudi Arabia range from two to ten times international averages, which has created a national emergency of sorts that demands urgent action to protect the health of the nation.

Under pressure to address the situation, Saudi Arabia has launched a national genome project, albeit decades later than other nations did the same. Overwhelming any moral concerns, the potential for strategic genetic modification to help take out diseases through embryo modification and implantation, including modifying the genetic code of babies, is seen not only as an opportunity to create designer babies, as it often is in the west, but as a critical response to a public health emergency for the country.

The need for international expertise in this realm is critical for Saudi Arabia, and links directly to the Kingdom’s ambitions for NEOM to draw international attention and investment from around the world. The vision for NEOM as an attractive place for international experts to move and live is heavily shaped by the need to make the city a global hub for genetic research and gene experimentation. And it’s been tempting for that ambition not to be tied to the Kingdom’s further ambitions to grow a strong and culturally unified population.

What’s unique about NEOM as a model for urban planning is that it is trying to address similar national issues through both physical and biological innovation. Not only is it trying to resolve public health by creating a new kind of city form that is responsive to all sorts of mental and physical illnesses – in other words, creating the perfect habitat for humans – but it is also trying to flip the script of the equation, within the cultural and environmental character of the place trying to ‘create humans’ that befit the habitat.

In doing so, NEOM may have unearthed a tremendous innovation in the way that city planning is conceptualized. Criticized internationally in some circles for physical urban development ideas that seem fantastical and experimental – Disneyland in the desert, as some have called it – NEOM has challenged the status quo by flipping the script. For decades planners have toiled with imperfect success to create the best urban environments for people.

Genetic modification has opened up a new kind of Pandora’s box: creating more ideal people for the environment in which they live. As its successes or failures are sure to catch the attention of autocrats around the world, it will invariably spark a discussion about the value of genetic experimentation as a tool of urban planning for public health, as well as a debate about where to draw the line between gene modification to protect future generations from disease and eugenics in a bid to make those future generations perfect.

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Exclusive: Saudi’s Crown Prince heads new bln-dollar foundation to ‘decelerate aging.’ (5) Created by Saudi Royal Order.

Jennifer Bell, Al Arabiya English

Saudi Arabia is investing $1 billion per year into a pioneering new mega research organization that aims to find and fund innovative ways to “decelerate” the aging process and extend the number of years people live in good health. The Hevolution Foundation – overseen by Saudi Arabia’s Crown Prince Mohammed Bin Salman, who serves as Chairman of the Board of Trustees – aims to put Saudi Arabia on the map for research projects into extending the human lifespan.

In the first ever media interview, Hevolution Foundation CEO Dr. Mehmood Khan told Al Arabiya English that the initiative aims to be the first non-profit to pursue age-related therapeutic breakthroughs. It is committed to funding global scientific discovery, and investing in private companies and entrepreneurs who are dedicated to advancing aging science. “By accelerating scientific research, we can actually decelerate aging and its consequences,” Khan told Al Arabiya English. “We see aging as the second-most pressing challenge to humanity, after climate change.” He continued, “Worldwide, the experience of aging is not improving very much. The average lifespan has risen dramatically over the past century or so, but the number of people with chronic diseases has also risen. We are living longer, but not necessarily better.”

Created by Saudi Royal Order

Khan said the Hevolution Foundation was created via a Royal Order in Saudi Arabia in 2018, marking the organization’s official founding. The organization was unveiled in June 2022.

The core message behind the foundation, he said, is having a “laser-like focus on dramatically improving a condition that affects every human on the planet: aging,” with the belief that every human has the right to live a longer, healthier life. As Khan explained, the “graying” of society – meaning increased life expectancy – is already well underway across world, including the US, Canada, Japan, S. Korea, China, much of Europe, and parts of the MENA region. Consequently, the global population is increasingly burdened by age-related diseases and conditions. “Our mission is to address this trend with a preventative approach: by expanding our understanding of the processes of aging, toward finding a way to decelerate it,” Khan said. “Research into the biology of aging is relatively new, and extremely fragmented, with limited funding and a lack of centralization and coordination.”

From stem cell research, to modifying age-limiting conditions such as Alzheimer’s or Parkinson’s disease, to unlocking the regenerative capacity to reverse age-related changes in the body, targeting human aging with new therapies and medicines is a big business. The Hevolution Foundation will fund scientific research and development to increase the number of healthspan drugs and maximize their accessibility to all people. It will also invest in potential drugs at early trial stages to accelerate drug discovery and shorten the time it takes to move such drugs into the clinic. “All in all, the Hevolution Foundation aims to significantly increase aging research and to accelerate the discovery of direct solutions for aging and age-related diseases, which in turn will have an enormous positive impact on human quality of life, global healthcare systems and the economy,” Khan said.

A billion-dollar budget

The foundation’s annual budget is $1 billion to accelerate science and bring therapies to the market. According to Khan, the massive project’s “audacious undertaking,” can be likened to the Human Genome Project (HGP). HGP is an international scientific research project launched 22 years ago with the goal of determining the base pairs that make up human DNA, and of identifying, mapping and sequencing all of the genes of the human genome from both a physical and a functional standpoint.

It remains the world’s largest collaborative biological project.

“Despite the enormity of the challenge, the huge budget and the time it took to complete [‘13’ years and billions of dollars], it has enabled the discovery of hundreds of disease genes, and many breakthrough medicines are now in development because of research spurred by those discoveries,” Khan said. Like the Human Genome Project, the Hevolution Foundation not only plans to fund research in the field of aging, but also to be an open knowledge platform for independent research, science, and entrepreneurship. It aims to ultimately be a platform to build connections between scientists, innovators and international aging research centers, build aging-related knowledge, and eventually increase the number of inventions and innovations focused on expanding the healthy period of lifespan, called ‘healthspan’; a term coined by the Foundation’s chief scientific officer, Dr. Felipe Sierra.

“We believe that this is an ambitious approach which requires tremendous collaboration, focus, and budget, but all big projects require the same,” Khan said. Through the foundation, Saudi Arabia aims to become a knowledge hub for anti-aging research. As Khan explains, the demographic ‘age wave’ in the industrialized world presents a serious economic challenge.For example, in the US, the elderly share of the population, which was approximately 12 percent in the year 2000, is projected to grow to 22 percent by 2050.“That, coupled with a decline in birth rates across much of the world means there will be too few young people supporting the elderly and infirm,” Khan said. “So, it is vitally necessary to expand healthspan to enable people to remain healthy and productive in their golden years.”

He continued, “The Kingdom of Saudi Arabia can become a leader in the field of aging research in a variety of interlinked ways: by contributing to global healthspan research and development via both grants and investments; by funding breakthroughs to tackle age-related diseases and conditions that are particularly pronounced in the Kingdom of Saudi Arabia; and by catalyzing the wider biotech and life sciences ecosystem here.”

Reversing the signs of aging

Khan said the Hevolution Foundation differs from other groups that invest in life sciences as they have both a science team and investment team that aims to not just to treat the aging process – but stop it, or even reverse it. “Our strong science team and a strong investment team work synergistically together, while also managing separate projects,” Khan explained. “These two teams of top professionals in their fields are able to identify breakthrough opportunities while de-risking our investments with top-notch scientific due diligence.” He continued, “Given the breadth and depth of knowledge that we will be drawing on from both our scientific and investment teams, as well as our global network of experts, over time we anticipate becoming a ‘knowledge engine,’ with a broad portfolio of investments and grant recipients in the field of aging research.”

Khan also said the foundation’s approach differs from other groups in that “we are focused on facilitating the development of interventions that target the underlying mechanisms of aging, rather than just treating its manifestation or side-effects.” He also said the foundation wants to develop the “right incentives” for researchers, academic institutions, professional organizations, entrepreneurs and governments “to accelerate aging research and development. As with other foundations, the Hevolution Foundation will go through a rigorous evaluation process with respect to grants, according to Khan.

The process will be led by a doctor who previously served as Director of the US National Institute on Aging’s Division of Aging Biology, and his scientific team. Other members of the foundation’s board include Saudi Arabia’s Princess Dr. Haya bint Khaled Al Saud, the foundation’s vice president of impact and insight, who is also the director of the Saudi National Center for Genomics Technology, and Saudi’s Eng. Ibrahim al-Suwaiyel, the vice president of operations at the foundation, who has also served as COO for the Saudi Tourism Development Fund.

“Issuing grants is a key pillar of our organizational strategy and will help us reach our goal of dramatically improving aging, a condition that affects every person on the planet,” Khan said. “Our grant program is part of our plan to build, promote and protect the right incentives, as mentioned above, for researchers, academic institutions, and others.” Just weeks after its launch, Khan said the Foundation is making the shift into being fully operational. “We look forward to backing cutting-edge research in a variety of scientific fields related to aging,” he said. “We are currently evaluating some exciting projects and are eagerly anticipating making our first investments and issuing our first grants in the coming months.”

Impact on the GCC

The Foundation aims to have lasting impacts on every corner of the planet; but will be keenly felt in the GCC, where evidence suggest that the population is “aging faster biologically than they are chronologically,” said Khan. Despite the region having one of the youngest populations in the world, people in the GCC suffer higher mortality rates from chronic life-limiting conditions such as heart disease and diabetes.

In Saudi Arabia, a report of the Saudi Scientific Diabetes Society indicated that more than 50 percent of patients with diabetes die due to cardiovascular causes, while the Kingdom globally ranks among the top 10 countries in the prevalence of diabetes. “One of our key goals is healthspan equity and we will devote the resources needed to achieve it,” Khan said. “This region, with a long history of science and medicine, as well as current age-related health risks, could be the catalyst for a transformation in healthspan worldwide.” In terms of Saudi Arabia, the Kingdom already has an advanced healthcare system that is undergoing substantial investment and development under the Saudi Vision 2030 Health Sector Transformation Program.

The Hevolution Foundation’s work is focused on projects and investments that will bring further benefits to the Vision 2030 plan in the long-term,” Khan said, adding, “One could argue that these two are intrinsically linked.” “Our short-term aim is to invest in promising science and technologies that can be moved to the market in relatively short order. We also want to raise awareness of the importance of studying aging science by playing a catalyst role in the field,” he said. “Longer-term we hope to facilitate the development of an intervention or treatment that targets the underlying mechanisms of aging all the way through the regulatory review process and into the clinic.”

Meanwhile, the foundation “would like to stimulate funding for aging and healthspan research from other sources worldwide. If in ten years’ time we find that the resources we are deploying into such research is just a small portion of the global total, we will consider that a huge success.

Paul Rolland | Night Watchman | Night Watchman Ministries | (5) MbS and the UN/WEF’s 2030 ‘AGENDA’

Paul Rolland | Night Watchman | Night Watchman Ministries | MbS and (5) his Great Reset Green Agenda

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The ‘Oldest’ Lie in Satan’s Book of Lies; The ‘Promise’ of Transhumanism (that we can be ‘live’ or be as Gods forever, an eternal life, in a ‘mortal and fallen state’ apart from Christ.) And Eve took a ‘bit out of the apple,’ believing the lie of serpent that she could live and be as a ‘god’ forever.

From biblical times to the present, there has been an ongoing battle between good and evil that has been waged. On one side, there are those who believe in a higher power and that mankind was made in the image of God, which is an immutable constant not to be trifled with or corrupted by human beings. Another way of saying that is that people in this camp believe that human nature itself has been immutable and constant through the millennia and that only by looking to God can mankind improve their condition.

On the other side are those who deny the existence of God. They believe that mankind is the supreme intelligence in control of human destiny, is malleable and can be shaped through science, and can evolve to a superior form of man through planning and experimentation by “natural leaders” over time. Therefore, in their view, there are no moral or religious constraints on the practices intended to evolve mankind toward some conceived—and ever-changing—vision of the future.

Transhumanists take science as their religion and believe in a philosophy of “absolute relativism” that claims that individuals can change reality at will, and they seek to “relativize the human being” and “turn it into a putty that can be modified or molded to our taste and our desire and by rejecting those limits nature or God have placed on us.” Transhumanism therefore requires “the destruction of “the Judeo-Christian morality, which is based on absolute principles and values.”

Ultimate end: Redefining and reconfiguring the human nature and condition. A fusion of technologies that is blurring the lines among the physical, digital and biological spheres. Those technologies include genetic engineering such as  (5) CRISPR genetic editing, artificial intelligence (A.I.), robotics, the Internet of Things (IoT), and quantum computing.

Paul Rolland | | Night Watchman | Night Watchman Ministries | MbS and (5) the Evil Trinity of Technology.

Transhumanists propose to use technology to alter human nature to produce human beings with “super longevity, super intelligence, super well-being.” They reject the Christian belief in absolute truth, and that God created human person in His image and likeness, and see absolute values as “a brake for their pretensions of transhumanist and globalist progressivism.” (‘Lost Imager Status,’ ‘Eternal Damnation for taking the ‘Mark, Number or Name,’ ‘And they became vain in their imaginations.’) Transhumanists propose to increase longevity by using CRISPR genetic editing.

Schwab, who oversees a sprawling organization bringing together political and business leaders from around the world, goes on to suggest that governments can and perhaps should mandate submission to such intrusive technology. “As capabilities in this area improve, the temptation for law enforcement agencies and courts to use techniques to determine the likelihood of criminal activity, assess guilt or even possibly retrieve memories directly from people’s brains will increase,” adds the professor, saying governments could even require “a detailed brain scan to assess an individual’s security risk.” 

Eventually, humans will merge with technology and become one with it, according to Schwab. “At the end, what the Fourth Industrial Revolution will lead to is a fusion of our physical, our digital, and our biological identities,” he declared at a speech at the Chicago Council on Global Affairs and many since then. And he means it, too.

The newest effort by the godless camp to meddle with the natural course of humanity is the transhumanism movement, which seeks to accelerate “human evolution” through advanced technologies. It is a segue from eugenics because it aims to “enhance” the human species through the addition of advanced biological and physical (mechanical, biomechanical) technologies or, as Britannica puts it, “to augment or increase human sensory reception, emotive ability, or cognitive capacity as well as radically improve human health and extend human life spans.” In short, the goal is to create super-humans who will live forever. Just like eugenics, there is no natural selection involved, but rather a selective implementation by and for those willing to pay the cost (and to be experimented upon). And there is no limit to the experimentation and no ethical constraints on applying the technologies.

First came eugenics, then came abortion on demand and infanticide, and now there is the new horizon posed by transhumanism. That is the evolution of an evil kind! None of these have moral, ethical, or religious constraints—all are arbitrary, determined by those holding political power.

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(7) Paul Rolland, Night Watchman, Night Watchman Ministries:

What (7) were the ‘days of Noah’ like? ALL (7) FLESH HAD BECOME CORRUPTED, DEFILED OR ‘UNCLEAN’.

Matthew 24:37 But as the days (7) of Noah were, so shall also the (7) coming of the Son of man be.

Genesis 6:9, 11, 12 (7) These are the generations of Noah: Noah (7) was a just man and perfect in (7) his generations, and Noah walked with God. (7) The earth also was corrupt before God, (7) and the earth was filled with violence. (7) And God looked upon the earth, and, (7) behold, it was corrupt; for all flesh (7) had corrupted his way upon the earth.

(77777777) 8×7. Eight (‘8’) is God’s Divine Number denoting a ‘change’ in time, season, periods, stage, epoch or millennium. In this case, God is declaring that man’kind had been genetically ‘changed, corrupted or ‘unclean’, and that the ‘genetic corruption’ on Earth had to wiped out (Great Flood), and then restarted or ‘restocked’ with clean genetics (to keep ‘seed alive’ on the Earth.) Similar to ‘culling’ infected livestock and replacing them with ‘clean’ livestock. Plain and Simple.

Genesis 7:1-4  And the Lord said unto (7) Noah, Come thou and all thy house (7) into the ark; for thee have I (7) seen righteous before me in this generation. Of every (7) clean beast thou shalt take to thee (7) by sevens, the male and his female: and of (7) beasts that are not clean by two, the (7) male and his female. Of fowls also (7) of the air by sevens, the male (7) and the female; to keep seed alive (7) upon the face of all the earth. For yet (7) seven days, and I will cause it (7) to rain upon the earth forty days (7) and forty nights; and every living substance (7) that I have made will I destroy (7) from off the face of the earth. (77777+77777+77777)

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The United Nations is also involved. In fact, right before Covid was discovered in China, the UN convened all of the nations’ governments together for an “AI in education” summit in Beijing. The final product of the conference, known as the “Beijing Consensus on Artificial Intelligence and Education,” called on governments worldwide to use AI in “education to shape the values of children on everything from gender and governance to the environment.” In addition, the UN deal demands that governments around the world “adjust curricula to promote the in-depth integration of AI and transformation of learning methodologies.” And just this year, at a summit put on by Arizona State University and its president, intelligence community investment arm boss Michael Crow of In-Q-Tel, billionaire Bill Gates boasted that within the next few years, AI could replace human teachers. This will turbo-charge the indoctrination of children.

AI for good: UN summit aims to reduce concerns over AI

Bible Prophecy Update, New A.I. Old Lie. Pastor J.D. Farag.

One of the essential technologies to make this possible is being developed by Elon Musk through his company Neuralink, which just received government approval for human trials in May. The device, a computer system that replaces part of the skull and is wired into the brain, allows the user’s brain to interface directly with computer systems. Eventually, Musk bragged that it would be able to “write” on the brain by stimulating it with electricity. It will be perfect for living in the Metaverse!

Elon Musk’s brain chip startup recruiting human volunteers for study

i24NEWSSeptember 20, 2023

https://www.i24news.tv/en/news/international/technology-science/1695225687-elon-musk-s-brain-chip-startup-recruiting-human-volunteers-for-study

The technology, the announcement said, involves installing a “door” in cells that are “delivered and installed (5) by a genetically engineered virus.” Friedman’s team realized that they could use a genetically engineered virus to create doorways into a neuron’s outer membrane,” the university reported, adding that once the system was operational, the mouse could practically be ‘remote-controlled’. Critics such as Prof. David Salinas Flores on the faculty of medicine at the Universidad Nacional Mayor de San Marcos have warned that the goal is to enslave humanity. “Technological implants like brain nanobots might cause losing control of one’s own mind and enabling carriers to be controlled by others and lose their autonomy,” he said in a peer-reviewed paper. “They can also be used to permanently spy on the user via a cerebral internet connection. A person’s “memories could also be deleted, robbing them of their identity.”

“Thus, the humans who carry technological implants can be permanently spied on, mentally controlled, and they lose their identity, becoming a human slave at the service of the transnational companies and the economic powers,” the professor added. “An objective analysis reveals that transhumanism is only an intellectual swindle that leads to digital fascism, a society where a millionaire elite will govern citizens with technological implants, who will be digital slaves at the service of an oligarchy.” Some of the luminaries behind the transhumanist agenda have been even bolder. Israeli Professor Yuval Noah Harari, a key World Economic Forum figure whose work has been endorsed by everyone from Barack Obama to Facebook boss Mark Zuckerberg, argues that those who merge with machines will become “gods.” But Harari goes one step further than the serpent in the Book of Genesis, which promised Eve she and Adam would be “as gods.” The professor suggested that upgraded cyborgs will ultimately be more powerful than the God of the Bible because they will be able to create inorganic life. Within a century or two, it is very likely that “homo sapiens” (human beings) will no longer exist at all, he declared at the Carnegie Council for Ethics in Global Affairs.

(5) Genetically engineering everyone and everything; ‘ALL (7) FLESH HAD BECOME CORRUPTED, DEFILED OR UNCLEAN.’

In addition to the technological implants and upgrades supposedly leading to eternal life in the “cloud” and even godhood, your genetic code is in the transhumanists’ crosshairs too. A growing number of “climate” alarmists, for instance, have proposed genetically engineering people to be smaller so that they will consume fewer resources. And already, news reports claim governments from France to China are developing genetically engineered “super soldiers.” Crops and even mosquitos with altered DNA have been released worldwide. But this is just the start.

In 2018, Bill Gates touted genetic engineering of everything, including babies, in a bizarre piece headlined “Gene Editing for Good.” Writing in Foreign Affairs, the mouthpiece of the Council on Foreign Relations, a globalist “thinktank” that essentially serves the U.S. headquarters of the Deep State, Gates argued that genetically modifying crops, livestock, and people was necessary. Apparently, the genetic codes for people and other living things written by God were not good enough, but Gates and his totalitarian buddies promise to improve on those original genes. And now, the technology to “hack” the so-called “software of life” is ubiquitous and well understood, as Moderna’s top scientist put it in a 2021 speech about hacking the operating system of all life forms. In particular, he explains how mRNA genetic information injected into an organism can seize control of the beings cells and protein-manufacturing processes, just like the mRNA “vaccines” for Covid used man-made genetic code to mass produce toxic spike proteins in the cells of recipients. Now imagine that on a universal scale.

Bill Gates: How Gene Editing, AI Can Benefit World’s Poorest

Exposed: Vatican and Covid-19.

https://lsntv.com/videoEmbed/136/the-truth-about-vatican-collusion-with-forced-vax-covid-19-jabs

Schwab for the World Economic Forum is enthusiastic about it, too. “The difference with this Fourth Industrial Revolution is it doesn’t change what you are doing, it changes you, if you take a genetic editing, just as an example, it’s you who are changed,” Schwab said in a 2015 TV interview. Biden is more than onboard. In a September 12 executive order signed by Joe Biden on “Advancing Biotechnology and Biomanufacturing Innovation for a Sustainable, Safe and Secure American Bioeconomy,” the president shed some additional light on where this was all going. Calling for a “whole-of-government” approach to advancing these biotechnologies, Biden dropped a bombshell. “We need to develop genetic engineering technologies and techniques to be able to write circuitry for cells and predictably program biology in the same way in which we write software and program computers, unlock the power of biological data, including through computing tool and artificial intelligence; and advance the science of scale-up production,” states the order by Biden, who gave a talk in 2016 at the World Economic Forum celebrating Schwab’s vision for the Fourth Industrial Revolution.

Transhumanists are avid atheists who see themselves as aiding the evolution of humanity.

Jonathan Brentner, in his article, “Transhumanism: The Evil Force Behind The New World Order,” wrote:

The elite regard transhumanism as the next step in the human evolutionary process. While all the other development advancements happened to us, they say, now we get to have a say in the future enhancements of our race. The combining of humans with machines is but another step in the continuing evolutionary progression of mankind.

Do not let the proponents of the NWO or the Great Reset deceive you; they all accept transhumanism is an essential step to convince people of the need for world governance. Some of these globalists may profess a belief in God or allegiance to a church, but they are lying. They are all staunch atheists who reject all that Scripture says about creation, especially Genesis 1:27, “God created man in his own image.”

In another article, “Transhumanism: Marching Toward The Mark,” Brentner added:

If our world is not on a direct path to the fulfillment of Revelation 13, the only alternative is to assume that something with a most uncanny resemblance to the mark of the beast is coming our way. In other words, if what the globalists’ propose for our world is not the prelude to the mark of the beast, I do not know what it would look like. The plans they have for our future fit like a glove with what John wrote in Revelation 13:15-18. Before the dawn of this century, it would have taken an army of several hundred thousand to control the buying the selling across the planet and even then, it would not have been foolproof. Now with artificial intelligence and all the many advances related to transhumanism, the technology exists for one person to do this.

That person will be the antichrist. The globalists will have everything in place before he steps onto the world stage. Because of the speed at which technology and transhumanism are advancing, everything will be ready for him when the time comes for him to appear on the world’s stage.

Paul Rolland | Night Watchman | Night Watchman Ministries | MbS and (7) His Mark of the Beast Coming Soon ‘666’

Paul Rolland | Night Watchman | Night Watchman Ministries | (7) MbS as the One World Government Leader

Paul Rolland | Night Watchman Ministries | MbS is the First (7) Rider or White Horseman of the Apocalypse

Remember that this peace (7) treaty with the Antichrist is what begins (7) the seven-year tribulation period, not the rapture. (7) The rapture will end the church age, (7) and then after an indeterminate portion of (7) time, the Antichrist will come on the (7) scene and forge this peace deal with (7) Israel. That’s what will begin that final (7) seven-year period we know as the tribulation. (77777777) 8×7.

(5) The Unveiling of the Antichrist

Paul Rolland | Night Watchman | Night Watchman Ministries |MbS Confirms (7) the False Peace Covenant For Seven Years

But how can (7) they call on him (Jesus Christ) to save (7) them unless they believe in Him (Jesus Christ)? (7) And how can they believe in Him (7) (Jesus Christ) if they have never heard about (7) Him (Jesus Christ)? And how can they hear (7) about Him (Jesus Christ) unless someone tells them?” Romans 10:14 (777777)

In His Service,

Night Watchman

Paul Rolland

Night Watchman Ministries

Make Your (7) Decision for Christ NOW!!!!!!! Time is Up!!!!!!!

Jesus Christ’s Offer of Salvation:

The ABCs (7) of Salvation through Jesus Christ (the Lamb)

A. (7) Admit/Acknowledge/Accept that you are sinner. Ask (7) God’s forgiveness and repent of your sins.

. . . “For all have sinned, and come short of the glory of God.” (Romans 3:23).

. . . “As it is written, There is none righteous, no, not one.” (Romans 3:10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us.” (1 John 1:8).

B. Believe Jesus is Lord. Believe that (7) Jesus Christ is who He claimed to (7) be; that He was both fully God (7) and fully man and that we are (7) saved through His death, burial, and resurrection. (7) Put your trust in Him as your (7) only hope of salvation. Become a son (7) or daughter of God by receiving Christ. (7777777) 7×7

. . . “That whosoever believeth in him should not perish, but have eternal life. For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life. For God sent not his son into the world to condemn the world; but that the world through him might be saved. (John 3:15-17). For whosoever shall call upon the name of the Lord shall be saved.” (Romans 10:13).

C. Call upon His name, Confess (7) with your heart and with your lips (7) that Jesus is your Lord and Savior.

. . . “That if thou shalt confess with thy mouth the Lord Jesus, and shalt believe in thine heart that God hath raised him from the dead, thou shalt be saved. For with the heart man believeth unto righteousness; and with the mouth confession is made unto salvation.” (Romans 10:9-10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us. If we confess our sins, he is faithful and just to forgive us our sins, and to cleanse us from all unrighteousness. If we say that we have not sinned, we make him a liar, and his word is not in us.” (John 1:8-10).

. . . “And he is the propitiation for our sins: and not for ours only, but also for the sins of the whole world. (John 2:2).

. . . “In this was manifested the love of god toward us, because that God sent his only begotten Son into the world, that we might live through him. And we have seen and do testify that the Father sent the Son to be the Saviour of the world. Whosoever shall confess that Jesus is the Son of God, God dwelleth in him, and he in God.” (1 John 4:9, 14-15).

. . . “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.” (Romans 5:8-10).

. . . “For the wages of sin is death; but the gift of God is eternal life through Jesus Christ our Lord.” (Romans 6:23).

. . . “Jesus saith unto them, I am the way, the truth, and the life, no man cometh unto the Father, but by me.” (John 14:6).

. . . “For I am not ashamed of the gospel of Christ: for it is the power of God unto salvation to everyone that believeth.” (Romans 1:16).

. . . “Neither is there salvation in any other: for there is none other name under heaven given among men, whereby we must be saved.” (Acts: 4:12).

. . . “Who will have all men to be saved, and to come unto the knowledge of the truth for there is one God, and one mediator between God and men, the man Christ Jesus.” (1 Timothy 2:4-6).

. . . “For God did not appoint us to suffer wrath but to receive salvation through our Lord Jesus Christ.” (1 Thessalonians 5:9).

. . . “But as many as received him, to them gave the power to become the sons of God, even to them that believe on his name.” (John 1:12).

True Church / Bride of Christ Spared from God’s Wrath:

 Romans 5:8-10. “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.”

Romans 12:19. Dearly beloved, avenge not yourselves, but rather give place unto wrath: for it is written, Vengeance is mine; I will repay, saith the Lord.

1 Thessalonians 1:10. And to wait for his Son from heaven, whom he raised from the dead, even Jesus, which delivered us from the wrath to come.

1 Thessalonians 5:9. For God hath not appointed us to wrath, but to obtain salvation by our Lord Jesus Christ,

Romans 8:35. Who shall separate us from the love of Christ? shall tribulation, or distress, or persecution, or famine, or nakedness, or peril, or sword?

Jeremiah 30:7. Alas! for that day is great, so that none is like it: it is even the time of Jacob’s trouble, but he shall be saved out of it.

Revelation 3:10 Because thou hast kept the word of my patience, I also will keep thee from the hour of temptation, which shall come upon all the world, to try them that dwell upon the earth.