Artificial Intelligence

Bioprocessing Warms to Artificial Intelligence. Attracted by the prospect of lower costs and shorter timelines, biomanufacturers are experimenting with deep learning, predictive analytics, and other AI technologies. Artificial intelligence (AI) is poised to transform the pharmaceutical industry. “AI as a technology that provides a solution to a problem that is better than a human’s solution.”

Ezekiel 33:2-6

“”When I bring the sword upon a land, and the people of the land take a man from their territory and make him their watchman,

3, when he sees the sword coming upon the land, if he blows the trumpet and warns the people,

4, then whoever hears the sound of the trumpet and does not take warning, if the sword comes and takes him away, his blood shall be on his own head.

5, He heard the sound of the trumpet, but did not take warning; his blood shall be upon himself. But he who takes warning will save his life.

6, But if the watchman sees the sword coming and does not blow the trumpet, and the people are not warned, and the sword comes and takes any person from among them, he is taken away in his iniquity; but his blood I will require at the watchman”s hand.” (Ezekiel 33:2-6)

Revelation 19:20 

And the beast was taken, and with him the false prophet that wrought miracles before him, with which he deceived them that had received the mark of the beast, and them that worshipped his image. These both were cast alive into a lake of fire burning with brimstone.

Revelation 14:11

And the smoke of their torment ascendeth up for ever and ever: and they have no rest day nor night, who worship the beast and his image, and whosoever receiveth the mark of his name.

Pastor Mike Taylor;

Each of us are watchmen on the wall. If you stand behind a pulpit or preach to a congregation in whatever media you use, you have a responsibility to warn those who are in danger of hell fire and all that it represents. God does not send anyone to hell, as it is a decision that each of us must make, but the Word of God must start with men and women who are commissioned by God to take the Word of Truth to those who are in their sins.

Whether a minister believes he is a watchman or not, he is commissioned by God to spread the Gospel to the lost. He is to preach the penalty of sin. He is to abandon a feel good “gospel”, prosperity gospel, or a social speech of humanism and being just a “good citizen”. This won’t save anyone. It will not warn those who are walking the wide road and gate to destruction, but will only placate them that they are OK…they are not OK, as they do not have Jesus in their hearts. It is a minister’s job to take the message of salvation to his congregation, his community and the rest of the world.

Jan Markell, Olive Tree Ministries;

Prepping for ‘Mr. Fix-It’

 Society is being prepped for the Antichrist, and as prophecy-loving believers try to warn, the words are falling on a lot of deaf ears.

 The stage is being set for a closing act. The players are getting into their proper positions. Heads of state are meeting to plot and scheme and deny even more rights. In places like Australia, Lithuania, and Austria, good people are enemies of the state even though they are upstanding citizens.

 World leaders have no comprehension they are majoring in minors. To them, it makes perfect sense to obsess over carbon emissions. During the Tribulation, this will fade from their memories as they cope with Seals and Trumpets and Bowls. These will spark “climate change” they cannot imagine!

 Most receiving this newsletter are “watchmen.” Ezekiel 33 tells us that if you don’t warn, the blood is on your hands, so you cannot be silent.

 Brace yourself to be shocked daily by things you read and watch. Satan is getting more active, and wickedness is rising, so God’s people must shine more brightly.

 But for the believer, a glorious event will happen soon. It is known as the Rapture of the Church. It is any day. Any hour. Any minute. So don’t grow weary!

 And yes, if a believer is a Rapture skeptic, they get the surprise of their life someday soon. Then you’ll have the privilege of saying, “I told you so.”

 Won’t that be a glorious day?

Pastor Greg Laurie; Harvest Ministries

“God promises this in the book of Revelation, and He also gives us a promise of global peace. The Antichrist, however, will bring pseudo peace. During the first three-and-a-half years of the seven-year Tribulation, he will come across as a good guy. But in reality, he will be a bad guy. And the Scriptures say that he will use peace to deceive many. Ultimately, once Antichrist is taken out of the way, God will bring global peace.”

Paul Rolland, Night Watchman, Night Watchman Ministries

Robots / Transhumanoids

Joel 2 Blow ye the trumpet in Zion, and sound an alarm in my holy mountain: let all the inhabitants of the land tremble: for the day of the Lord cometh, for it is nigh at hand;

2 A day of darkness and of gloominess, a day of clouds and of thick darkness, as the morning spread upon the mountains: a great people and a strong; there hath not been ever the like, neither shall be any more after it, even to the years of many generations.

3 A fire devoureth before them; and behind them a flame burneth: the land is as the garden of Eden before them, and behind them a desolate wilderness; yea, and nothing shall escape them.

4 The appearance of them is as the appearance of horses; and as horsemen, so shall they run.

5 Like the noise of chariots on the tops of mountains shall they leap, like the noise of a flame of fire that devoureth the stubble, as a strong people set in battle array.

6 Before their face the people shall be much pained: all faces shall gather blackness.

They shall run like mighty men; they shall climb the wall like men of war; and they shall march every one on his ways, and they shall not break their ranks:

8 Neither shall one thrust another; they shall walk every one in his path: and when they fall upon the sword, they shall not be wounded.

9 They shall run to and fro in the city; they shall run upon the wall, they shall climb up upon the houses; they shall enter in at the windows like a thief.

10 The earth shall quake before them; the heavens shall tremble: the sun and the moon shall be dark, and the stars shall withdraw their shining:

A.I., Robots and ‘Transhumanoids’;

Bioprocessing Warms to Artificial Intelligence. Attracted by the prospect of lower costs and shorter timelines, biomanufacturers are experimenting with deep learning, predictive analytics, and other AI technologies. Artificial intelligence (AI) is poised to transform the pharmaceutical industry. “AI as “a technology that provides a solution to a problem that is better than a human’s solution.”

By Vivienne Raper, PhD, Vivienne Raper, PhD  August 3, 2020 Bio-Technology and Engineering News

Artificial intelligence (AI) is poised to transform the pharmaceutical industry. According to a 2017 report, AI solutions for drug discovery may generate revenues exceeding $4 billion dollars by 2024. Within the bioprocessing sector, AI is attracting interest because it promises to reduce costs and accelerate timelines.

“There’s a huge potential for using AI in manufacturing and bioprocessing,” explains Vimal Mehta, PhD, CEO and co-founder of BioXcel Therapeutics. “If you can start to use AI to optimize production processes or help upscale them, you can meet challenges we face today, such as how to scale up production of a vaccine for COVID-19.” (Night Watchman note; read ‘Infrared Vaccination Micro-Needle SMART Patch ‘MARK’ that uses non-refrigerated, genetically altering vaccines.)

Building upon mature technologies

Over the last 30 (5×6) years, the meaning of “artificial intelligence” has evolved, according to Richard D. Braatz, PhD, Edwin R. Gilliland Professor at the Massachusetts Institute of Technology. He prefers to refer to

This definition covers a huge range of technologies AI as “a technology that provides a solution to a problem that is better than a human’s solution.”, including pattern (‘mark’) recognition, predictive analytics, and deep learning. Some of these AI technologies are sufficiently mature to enhance drug research and development. “We already have products that are using AI,” declares Per Lidén, digital product management leader at Cytiva (formerly GE Healthcare). One such product is IN Carta, a cell image analysis software that includes a machine learning module called Phenoglyphs. With this module, IN Carta can automatically classify cells by phenotype.

Cytiva is investigating other AI applications. For example, it is using AI to improve the performance of cell cultures and optimize protein purification. “We’re in an interesting situation as an industry,” remarks Liden. “We have a great interest in AI when arguably we’re not yet industrialized to the extent of other industries.”

He expects the pharmaceutical industry to skip several early AI technologies to adopt cutting-edge infrastructure—rather like countries who came late to telephony and immediately adopted mobile phones.

BioXcel Therapeutics, meanwhile, is using machine learning and big data to identify novel uses of known drug classes. By reviewing millions of publications and extracting metadata in a few hours, the company quickly creates relationship maps that encompass agonists, receptors, symptoms, and other factors.

According to Mehta, the company used machine learning to identify a drug candidate called BXCL501, which has promise as a treatment for acute agitation in patients with schizophrenia, bipolar disorder, or dementia, as well as for delirium and opioid withdrawal. The company arrived at BXCL501, a proprietary sublingual thin-film formulation of dexmedetomidine, a sedative that has been on the market since 1999, after deciding to focus on neural symptoms and recognizing that agitation creates a high healthcare burden.

“This technology,” Mehta emphasizes, “allowed us to identify a unique mechanism of a well-known drug for indications no one had thought about.”

Putting AI into practice

Neither of BioXcel’s current drug candidates require advanced, AI-optimized bioprocessing, but Mehta understands its benefits and anticipates that it could be become relevant his company. “There’s a huge application of AI in manufacturing,” he explains. “There are so many steps involved in manufacturing those drugs and so many variables involved in [batch] production.”

Large biotech companies are beginning to investigate how AI can be incorporated into their manufacturing processes. “I am, for sure, looking into AI and how this technology can be used to optimize our operational processes,” writes Stephan Rosenberger, PhD, global head of digital transformation, LPBN Operations, Lonza.

He indicates that Capsugel, a Lonza company, is using machine learning on high-speed camera images to detect defective drug capsules so that capsule machines may automatically eject them. “We are in the process of collecting information on defects from all capsule machines in the global Lonza-Capsugel production network,” he continues. “Preliminary investigation into machine learning on images has been done, but combining image data with other data, such as raw materials data, is still in development.”

Boehringer Ingelheim is using advanced machine learning algorithms, such as neural networks, to optimize its manufacturing processes as part of a wider commitment to adopting digital technology across the company. Hermann Schuchnigg, who represents the company as “product owner SMART Digital Twin platform,” says that Boehringer Ingelheim wants to understand how to optimize procedures and reduce timelines throughout the process of bringing a new drug to market—from designing the manufacturing process to producing the drug.

“From a manufacturer’s perspective, we are looking at increasing productivity, ensuring robustness, and enabling market readiness as early as possible,” he explains. “Reducing timelines for process development and optimization has an impact on the time to market for new products.”

Optimization begins when a neural network, a set of intelligent algorithms, is “taught” to work with a digital model of a real process. Then, the intelligent algorithms refine themselves to give the model the best production efficiency, robustness, and reproducibility. Besides reflecting individual process stages, such as the chromatography step, the model gives a holistic view of the entire process chain.

Boehringer Ingelheim is currently evaluating its model as a means of optimizing process design, but the company intends to use its model as a means of optimizing process control. To achieve this goal with a real process, the company is working to give that process a full-fledged digital twin that can emulate the real process in real time.

“[If our model were to continuously acquire feedback from] our manufacturing systems, it could iteratively optimize the manufacturing process on the go,” Schuchnigg asserts. “While full-scale operationalization in manufacturing requires further technical and regulatory advancement, an initial prototype of this digital tool is currently in preparation, and the company expects first results later this year.”

Researching bioprocessing approaches

Academic researchers are examining how AI can improve bioprocessing. For example, a team of academic researchers recently showed how to improve co-culture bioprocesses with “deep reinforcement learning.” The team, which included Chris P. Barnes, PhD, professor of systems and synthetic biology at University College London, and Brian Ingalls, PhD, associate professor of applied mathematics at the University of Waterloo, Canada, described their work in a paper that appeared last April in PLoS Computational Biology. They detailed how a machine learning algorithm could be used to optimize the nutrients entering a bioreactor to sustain multiple microbial strains.

The machine learning algorithm received feedback on the amount of two species of Escherichia coli in five (5) virtual bioreactors running in parallel. By applying reinforcement learning, the researchers managed to train the algorithm to optimize product output within 24 hours.

According to Ingalls, the study shows that it’s possible for machine learning to perform as well as—or outperform—a predictive model where predetermined equations control the bioreactor system. “There’s no underlying predictive model,” he explains. “Instead, the regulator tries different actions and learns from its experience what works and what doesn’t.”

The study showed that a co-culture bioreactor system could be optimized using a reinforcement learning approach that works without the benefit of a prebuilt mathematical model. Such approaches, Ingalls believes, could be adapted by the pharmaceutical industry to control processes that are even more complex. He notes that pharmaceutical industry currently finds it hard to optimize for multiple species of microbe at the same time.

“What we’ve done is pretty novel,” says Barnes. Although the study was done using virtual bioreactors, he is now putting in a grant to move to benchtop scale. “We hope to demonstrate it in the next year or so in small tabletop bioreactors and then try to scale to 10 L in a pilot plant,” he continues. He adds that this would provide the expertise required to start a company and involve industrial partners. “Once we’ve shown it working,” he declares, “that will be an exciting time.”

Making intelligent decisions

A team led by Braatz is working on designing an intelligent “decision tree” for helping biopharmaceutical companies make better decisions based on the data collected from their processes. The decision tree selects the best data analytics software, based on the characteristics of the data, to produce the most accurate predictive models.

“In case studies, the software performs better than human experts and is fully automated,” he explains. “Consequently, users can focus on defining their problems and making decisions based on the models.”

Braatz and colleagues are currently developing decision trees for addressing more complex problems. They hope that the system will allow companies to speed process development, to bring approved drugs to market faster, and to reduce the losses that are incurred when drug candidates fail late in clinical trials.

Moving to the future

According to Barnes, reinforcement learning works only if there’s continuous feedback between the bioreactor and the algorithm. That requires online measurements, for example, near infrared (NIR) spectroscopy, where the absorption of NIR light by a sample reveals the sample’s composition.

“Once you go to continuous processing and you have online measurement, you can apply these AI techniques like reinforcement learning,” he says, pointing out that most companies still rely on batch processing. Relatively few companies have embraced continuous processing, which remains a technology for the future.

Other companies are applying AI to the emerging field of personalized medicine. GNS Healthcare has developed an “in silico patient,” a cause-and-effect model designed to predict which patients will respond (or not) to drug treatment. “We’re not the only people with predictive technology, that is, deep learning,” says Colin Hill, PhD, chairman, CEO, and co-founder of GNS Healthcare. “But no one else has causal AI and cause-effect technology designed for the biopharmaceutical world.”

According to Hill, the pharmaceutical industry could unravel the complexities of human biology more effectively with GNS Healthcare’s technology. The in silico patient, he insists, is an increasingly accurate model of a complex human response that is based on a cohort of patients.

Some of the company’s clients are applying this technology to optimize the manufacturing of chimeric antigen receptor (CAR) T-cell therapies. “What the example of CAR T-cell therapies shows is that, as AIs try to tame the complexity of human disease, it’s now becoming possible to move toward increasingly personalized treatments,” Hill declares. “And AI is going to be central to that.”

Night Watchman Note, regarding ‘INFRARED’ Technologies.

The Coming Infrared Biometric Vaccination Mark of the Beast System:

(Five (5); Digital ID, Vaccination Passport, Biometric Infrared Scanning, Vaccine ‘Mark’ or ‘code/number’ of Approval or Authorization, 5G Technology/Network.)

The ‘coming’ mark will most likely involve a ‘subdermal’ (non-hypodermic needle) application of the next wave of vaccinations, that will include a form of ‘digital data memory’ indicating date and time of vaccination. This ‘mark’ of vaccination will involve a sub-dermal outline or image representing a ‘branding’ that can be scanned and revealed by infrared light at a retail checkout point scanner. Just as many people have a physical vaccination ‘mark’ on their arm from getting shots in the 1960s, the coming vaccination mark will be subtle and reside ‘inside’ the human body affecting and indicating a genomic change in the recipient. This is an abomination viewed by God and causes the recipient to lose ‘Imager Status before God’ and results in eternal damnation. The vaccination ‘mark’ has to be easily accessible by scanners and retail checkout points, hence the recipient will have the option of receiving the vaccination ‘patch’ either on their hand or forehead for ‘scannability.’ The patch or medium itself ‘dissolves’ on the exterior of the skin, as the vaccination and information is administered or delivered under the skin. Some technology is currently under development that will possibly allow for the recipient’s health status and response to the vaccine to be ‘scanned’ and ‘verified’ or ‘validated’ at retail or social checkpoints. The purpose of which is to identify whether or not the vaccine has actually worked (and is working) on the recipient’s body / immune system / genetics / RNA / DNA, in addition to informing authorities as to date, time, dosage and manufacturer of said ‘medicine.’

False Prophet (The WORLD’S Greatest Social ‘Influencer’). ‘Go ahead, get the jab, it is good for you, it is good for humanity, it is the ‘moral’ thing to do.’

Revelation 13:16-17 And he [false prophet, pope, pontiff] causeth ALL, both small and great, rich and poor, free and bond, to receive a [‘subdermal, infrared, vaccination, smart’] mark IN their right hand, or IN their foreheads: And that no man might buy or sell, save he that had the [‘subdermal, infrared, vaccination, smart’] mark, or the name of the beast, or the number of his name. (Emphasis mine. Discernment mine.)

Revelation 19:20 

And the beast was taken, and with him the false prophet that wrought miracles before him, with which he [false prophet, pope, pontiff] DECEIVED THEM that had received the [‘subdermal, infrared, vaccination, smart’] mark of the beast, and them that worshipped his image. These both were cast alive into a lake of fire burning with brimstone. (Emphasis mine. Discernment mine.)

Revelation 14:11

And the smoke of their torment ascendeth up for ever and ever: and they have no rest day nor night, who worship the beast and his image, and whosoever receiveth the mark of his name.

Revelation 20:4

And I saw thrones, and they sat upon them, and judgment was given unto them: and I saw the souls of them that were beheaded for the witness of Jesus, and for the word of God, and which had NOT worshipped the beast, neither his image, neither had received his mark upon their foreheads, or in their hands; and they lived and reigned with Christ a thousand years.

5G + Biometric Facial / Hand Scanning + Digital / Cashless Transactions + Mark of Approval / Authorization = Tomorrow’s Economy (2020-2027). Why 2020? Because these ‘things’ have already occurred (past tense) elsewhere (China, India, Asia and a few countries in Europe) in the world in 2020, even though they have not yet occurred in the ‘United’ States.

Biometric scanning used for migrant/border control, secure identity verification and approval, government benefits, domestic and international travel security, economic inclusion of everyone, buying/selling transactions and fund transfers, instantaneous speed of transaction and convenience, VAT/taxation collection, mobility, social credit score and ranking, population movement and tracking, monitoring political and religious ‘extremism’ (terrorists). ‘Mark, number or name’ for verification and approval.

‘Any foreign material(s) should NOT be injected into the human body that causes any kind of change in genetic makeup or structure of a human being. This could be five (5) genetic ‘manipulation’, ‘enhancement’, ‘cutting’, ‘modification’, or ‘alteration.’

Revelation 16:2

And the first went, and poured out his vial upon the earth; and there fell a noisome and grievous sore upon the men which had the mark of the beast, and upon them which worshipped his image. [Symptom or result from having ‘received’ the mark, a result from having changed or damaged a person’s RNA, DNA, Immune System or Genetics].

Both American vaccines use messenger RNA (mRNA) to combat the virus. That is an advanced genetic therapy that uses the virus’ own genetic material against it. Kendrick, however, warns that the technology isreally new and untested, meaning no one really knows how it could affect human health, since it literally hijacks the cellular reproduction mechanism. “We really do not know what these things might end up doing after a prolonged period of time.”

“The plague year of 2020 will be remembered as the time when traditional vaccines were supplanted by something fundamentally new: genetic vaccines, which deliver a gene or piece of genetic code into human cells. The genetic instructions then cause the cells to produce, on their own, safe components of the target virus in order to stimulate the patient’s immune system.”

‘The MARK’ may not be here just yet, but it will be shortly … in terms of a year or two (2023). Verification that a ‘genetic manipulation’ has been administered and will be evident, either in the hand or in the forehead by infrared biometric scanning to enable travel, buying and selling. Do you still ‘want to take’ the jab even if it is not yet administered in your hand or in your forehead in some other manner? If you are curious, please read my other analyses on ‘why’ getting ‘the mark’ is such a bad (understatement) thing in the eyes of God. It is one thing to understand that people in the extremely near future should NOT GET THE MARK. It is another thing to UNDERSTAND WHY THEY SHOULD NOT GET A MARK. This is not a ‘conspiracy theory,’ but the Word of God. I have provided the requisite verses from the Bible, regarding God’s comments about ‘the mark’ of the coming world beast system.

NO ‘MICROCHIP’ NEEDED. Implantable Quantum Dot Microneedle Vaccine INFRARED Delivery System:

MIT researchers have now developed a novel way to record a patient’s vaccination history: storing the data in a pattern of dye, invisible to the naked eye, that is delivered under the skin at the same time as the vaccine. This technology could enable the rapid and anonymous detection of patient vaccination history. The researchers showed that their new dye, which consists of nanocrystals called quantum dots, can remain for at least five (5) years under the skin, where it emits [near-infrared light] that can be detected by a specially equipped smartphone. To create an “on-patient,” decentralized medical record, the researchers developed a new type of copper-based quantum dots, which emit light in the [near-infrared spectrum]. The dots are only about 4 nanometers in diameter, but they are encapsulated in biocompatible microparticles that form spheres about 20 microns in diameter. This encapsulation allows the dye to remain in place, under the skin, after being injected. The researchers designed their dye to be delivered by a microneedle ‘patch’ rather than a traditional syringe and needle. Such patches are now being developed to deliver vaccines for measles, rubella, and other diseases, and the researchers showed that their dye could be easily incorporated into these patches. The microneedles used in this study are made from a mixture of dissolvable sugar and a polymer called PVA, as well as the quantum-dot dye and the vaccine. When the patch is applied to the skin, the microneedles, which are 1.5 millimeters long, partially dissolve, releasing their payload within about two minutes.

By selectively loading microparticles into microneedles, the patches deliver a pattern in the skin that is invisible to the naked eye but can be scanned with a smartphone that has the [infrared] filter removed. The patch can be customized to imprint different patterns that correspond to the type of vaccine delivered. “It’s possible that this ‘invisible’ approach could create new possibilities for data storage, biosensing, and vaccine applications that could improve how medical care is provided, particularly in the developing world,” Langer says.

The quantum-dot patterns could be detected by smartphone cameras after up to five (5) years of simulated sun exposure. The researchers are also working on expanding the amount of data that can be encoded in a single pattern, allowing them to include information such as the date of vaccine administration and the lot number of the vaccine batch. “Storage, access, and control of medical records is an important topic with many possible approaches.” “This study presents a novel approach where the medical record is stored and controlled by the patient within the patient’s skin in a minimally invasive and elegant way.” The research was funded by the Bill and Melinda Gates Foundation and the Koch Institute Support (core) Grant from the National Cancer Institute.

APPLE FACE and PALM ‘INFRARED Photo Detectors’ biometrics planned in 2023 iPhones.

Face ID Infrared biometrics cameras are coming to Apple devices in 2023. A series of patent filings by Apple have hinted at the company’s work on under-display biometric cameras, with the latest published in February (2021).  Apple eyes next-generation biometric scanners for under-display Touch ID. ‘[Infrared photodetectors] could be used for biometric user identification and authentication in the palm or face.’ A new patent application by Apple is signaling the company’s emphasis on biometric ‘photodetector’ technology for under-display touch identification to be potentially deployed on its devices. The sensors include biometric sensors, depth sensors, and cameras. Apple’s listed uses of the photodetectors include security and health monitoring. Arrays of these photodetectors may be deployed to scan fingerprint, palm print, 3D face, or eye biometrics. The [photodetectors could be used for biometric user identification and authentication.] Photodetectors emit electromagnetic radiation against an object such as a finger, face, or stylus. Once reflected by the object, this radiation returns a backscatter which then passes back through the display to register the object’s information. The document also refers to the possibility of using optical, ultrasonic, thermal or other sensing technologies within the system. In addition to this, the photodetectors are also capable of obtaining ophthalmic scans, ECG, and pulse for health monitoring. Other uses of the scanners include palm scanning for social matching and social networking. Apple’s research and development of technology for monitoring health metrics, three patent applications describe [Infrared transceivers] for object recognition. The [infrared transceivers], which may be used in telephones include beam-steering technology and will likely be used for augmented object recognition via visible and [infrared light]. According to the filing, the device can sense objects in a variety of light conditions including visible light, UV, and [infrared spectrum] ranges.

Vaccine INFRARED ‘Micro-Needle SMART Patch’

“Nanocrystals called quantum dots, can remain for at least FIVE (5) years under the skin, forming an ‘image’, where they emit near-[infrared light] that can be detected by a specially equipped smartphone.” (MIT researchers FUNDED by the Bill & Melinda Gates Foundation).

‘Infrared’ Mark of the Beast, 2023 to 2028 = FIVE (5) YEARS.

FIVE (5) is the number denoting Satanic influence over the behavior of evil man’kind (666).

2023 ‘INFRARED’ SMART Phones

2023 ‘INFRARED’ VACCINE MICRO-NEEDLE SMART Patches

Come June, 2021 … 2023 is ONLY 18 (6+6+6) months in the future.

False Prophet

Revelation 13:16-17 And he causeth all, both small and great, rich and poor, free and bond, to [receive a mark IN their right hand, or IN their foreheads]:And that no man might buy or sell, save he that had the mark, or the name of the beast, or the number of his name.

My discernment is that;

2023 / 2024 will mark the ‘roll-out’ of the ‘MARK’ of the BEAST.

2025 will mark the ‘mid-point’ of the 7 Year Tribulation, the Abomination of Desolation revealing the BEAST to be the ANTICHRIST, the Destruction of ‘Mystery Religion’, the beginning of worshipping the BEAST and his IMAGE, and the ‘BEHEADING’ of those who refuse the  Beast’s MARK, refuse to worship the BEAST or his IMAGE. Until 2025, Christians will be ‘protected’ under the MYSTERY RELIGION doctrine of (5) ‘inter-religious dialogue, brotherhood, human fraternity, coexistence and false religious / political peace.’ Upon the enactment of the Antichrist’s Abomination of Desolation and the abolishment of the Mystery Religion, is when BOTH the Jews will become persecuted and have to flee Jerusalem AND Christians will start to be BEHEADED because they will refuse to get the mark and refuse to worship the BEAST and his IMAGE. Beheadings will last during the FINAL 3.5 years of the Tribulation (Great Tribulation) and cease at the end of 2028 / 2029.

God will NOT let Christ’s Bride be Deceived by the Dragon, or his ‘MARK.’

True Church / Bride of Christ Spared from God’s Wrath:

 Romans 5:8-10. “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.”

1 Thessalonians 1:10. And to wait for his Son from heaven, whom he raised from the dead, even Jesus, which delivered us from the wrath to come.

1 Thessalonians 5:9. For God hath not appointed us to wrath, but to obtain salvation by our Lord Jesus Christ,

Romans 8:35. Who shall separate us from the love of Christ? shall tribulation, or distress, or persecution, or famine, or nakedness, or peril, or sword?

Jeremiah 30:7. Alas! for that day is great, so that none is like it: it is even the time of Jacob’s trouble, but he shall be saved out of it.

Revelation 3:10 Because thou hast kept the word of my patience, I also will keep thee from the hour of temptation, which shall come upon all the world, to try them that dwell upon the earth.

The ‘mark’ comes shortly, during the tribulation, but the Bride is ‘not here.’ The ‘current’ vaccine(s) are NOT the mark, yet. But they are a ‘precursor’ (‘NORMALIZATION’) of the beast system process, getting people accustomed to getting ‘tagged’, ‘marked’ or ‘branded.’

8 References to ‘BE WATCHING or WATCHFUL.’ ‘8’ indicates that a new ‘era or epoch’ is arriving. Be it the rapture, the tribulation, the year of the Jews redemption or the year of the onset (2028) of the 1000 year millennial reign of Christ (2028-3028).

Matthew 24:42; Watch therefore: for ye know not what hour your Lord doth come.

Matthew 25:13; Watch therefore, for ye know neither the day nor the hour wherein the Son of man cometh.

Mark 13:35; Watch ye therefore: for ye know not when the master of the house cometh, at even, or at midnight, or at the cockcrowing, or in the morning.

Luke 21:36; Watch ye therefore, and pray always, that ye may be accounted worthy to escape all these things that shall come to pass, and to stand before the Son of man

Luke 12:37-39; Blessed are those servants, whom the lord when he cometh shall find watching: verily I say unto you, that he shall gird himself, and make them to sit down to meat, and will come forth and serve them. And if he shall come in the second watch, or come in the third watch, and find them so, blessed are those servants. And this know, that if the goodman of the house had known what hour the thief would come, he would have watched, and not have suffered his house to be broken through.

 ‘Increasing Like Labor Pains.’ ‘Fearful Sights.’ ‘Perilous Times.’ ‘Men’s hearts failing with fear.’ Great Convergence of Signs.’ REDEMPTION IMMINENT.

In His Service,

Night Watchman

Paul Rolland

Night Watchman Ministries

Make Your Decision for Christ NOW!!!!!!! Time is Up!!!!!!!

Jesus Christ’s Offer of Salvation:

The ABCs of Salvation through Jesus Christ (the Lamb)

A. Admit/Acknowledge/Accept that you are sinner. Ask God’s forgiveness and repent of your sins.

. . . “For all have sinned, and come short of the glory of God.” (Romans 3:23).

. . . “As it is written, There is none righteous, no, not one.” (Romans 3:10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us.” (1 John 1:8).

B. Believe Jesus is Lord. Believe that Jesus Christ is who He claimed to be; that He was both fully God and fully man and that we are saved through His death, burial, and resurrection. Put your trust in Him as your only hope of salvation. Become a son or daughter of God by receiving Christ.

. . . “That whosoever believeth in him should not perish, but have eternal life. For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life. For God sent not his son into the world to condemn the world; but that the world through him might be saved. (John 3:15-17). For whosoever shall call upon the name of the Lord shall be saved.” (Romans 10:13).

C. Call upon His name, Confess with your heart and with your lips that Jesus is your Lord and Savior.

. . . “That if thou shalt confess with thy mouth the Lord Jesus, and shalt believe in thine heart that God hath raised him from the dead, thou shalt be saved. For with the heart man believeth unto righteousness; and with the mouth confession is made unto salvation.” (Romans 10:9-10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us. If we confess our sins, he is faithful and just to forgive us our sins, and to cleanse us from all unrighteousness. If we say that we have not sinned, we make him a liar, and his word is not in us.” (John 1:8-10).

. . . “And he is the propitiation for our sins: and not for ours only, but also for the sins of the whole world. (John 2:2).

. . . “In this was manifested the love of god toward us, because that God sent his only begotten Son into the world, that we might live through him. And we have seen and do testify that the Father sent the Son to be the Saviour of the world. Whosoever shall confess that Jesus is the Son of God, God dwelleth in him, and he in God.” (1 John 4:9, 14-15).

. . . “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.” (Romans 5:8-10).

. . . “For the wages of sin is death; but the gift of God is eternal life through Jesus Christ our Lord.” (Romans 6:23).

. . . “Jesus saith unto them, I am the way, the truth, and the life, no man cometh unto the Father, but by me.” (John 14:6).

. . . “For I am not ashamed of the gospel of Christ: for it is the power of God unto salvation to everyone that believeth.” (Romans 1:16).

. . . “Neither is there salvation in any other: for there is none other name under heaven given among men, whereby we must be saved.” (Acts: 4:12).

. . . “Who will have all men to be saved, and to come unto the knowledge of the truth for there is one God, and one mediator between God and men, the man Christ Jesus.” (1 Timothy 2:4-6).

. . . “For God did not appoint us to suffer wrath but to receive salvation through our Lord Jesus Christ.” (1 Thessalonians 5:9).

. . . “But as many as received him, to them gave the power to become the sons of God, even to them that believe on his name.” (John 1:12).

True Church / Bride of Christ Spared from God’s Wrath:

 Romans 5:8-10. “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.”

Romans 12:19. Dearly beloved, avenge not yourselves, but rather give place unto wrath: for it is written, Vengeance is mine; I will repay, saith the Lord.

1 Thessalonians 1:10. And to wait for his Son from heaven, whom he raised from the dead, even Jesus, which delivered us from the wrath to come.

1 Thessalonians 5:9. For God hath not appointed us to wrath, but to obtain salvation by our Lord Jesus Christ,

Romans 8:35. Who shall separate us from the love of Christ? shall tribulation, or distress, or persecution, or famine, or nakedness, or peril, or sword?

Jeremiah 30:7. Alas! for that day is great, so that none is like it: it is even the time of Jacob’s trouble, but he shall be saved out of it.

Revelation 3:10 Because thou hast kept the word of my patience, I also will keep thee from the hour of temptation, which shall come upon all the world, to try them that dwell upon the earth.

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