Genetic Manipulation and Hybridization Update

Revolutionary CRISPR machine can edit hundreds of genes at once

Matthew 24:37 But as the days of Noah were, so shall also the coming of the Son of man be.

Genesis 6:9, 11, 12 These are the generations of Noah: Noah was a just man and perfect in his generations, and Noah walked with God. The earth also was corrupt before God, and the earth was filled with violence. And God looked upon the earth, and, behold, it was corrupt; for all flesh had corrupted his way upon the earth.

Genesis 7:1-4  And the Lord said unto Noah, Come thou and all thy house into the ark; for thee have I seen righteous before me in this generation. Of every clean beast thou shalt take to thee by sevens, the male and his female: and of beasts that are not clean by two, the male and his female. Of fowls also of the air by sevens, the male and the female; to keep seed alive upon the face of all the earth. For yet seven days, and I will cause it to rain upon the earth forty days and forty nights; and every living substance that I have made will I destroy from off the face of the earth.

Revolutionary CRISPR machine can edit hundreds of genes at once

Published time: 19 Aug, 2019 12:44Edited time: 20 Aug, 2019 09:16 RT

The revolutionary CRISPR gene editing machine has undergone an incredible upgrade to edit “dozens or even hundreds of genes” at once, allowing scientists to reprogram entire gene networks in one fell swoop.

Previously, in the best case scenario, the CRISPR-Cas technique could only modify a handful of genes simultaneously and usually it could only manage one at a time. However, new research opens up a world of possibilities for scientists to change cells on a much larger scale.  

“Our method enables us, for the first time, to systematically modify entire gene networks in a single step,” says the study’s author Randall Platt, from ETH Zurich in Switzerland. “Thanks to this new tool, we and other scientists can now achieve what we could only dream of doing in the past.”

The new method can hit 25 targets within genes at once, with the ability to hit hundreds more. It means instead of the time-consuming system of making one edit at a time, scientists can do more widespread alterations. 

The team behind the study does concede, however, that more edited genes mean a higher risk of unexpected secondary changes, like mutations or genetic damage. “Future work overcoming these limitations will open up numerous applications for highly multiplexed genome engineering,” reads the paper, published in Nature Methods.

Gene editing is a relatively new technology that allows scientists to rewrite DNA by correcting ‘bad’ genes, like genetic disorders, or adding new ones. It has been used to treat children that were predisposed to serious genetic illnesses or incurable cancers, as well as HIV patients.

The Crispr-Cas9, invented in 2012, is the leading molecular tool in gene editing. It allows doctors to zone in on a specific region of an organism’s genetic code and effectively disable a gene

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