Blog note. Jesus indicated that ‘fearful sights’ (various natural disasters) would occur leading up to the time known as the Tribulation and Great Tribulation (a combined seven year period of great destruction on earth). Although these types of things have occurred in the past for centuries and thousands of years, they could be identified as the ‘season of the times’ due to the ferociousness of these events. They would be occurring in greater intensity, severity, frequency, size, duration, scope … just like the pains that a woman experiences in labor the farther along she is in the labor process. We are in the ‘season of the times’ that comes just before the seven (7) year Tribulation/Great Tribulation period
… And great earthquakes shall be in diverse places, and famines, and pestilences; and fearful sights and great signs shall there be from heaven. (Luke 21:11).
… And there shall be signs in the sun, and in the moon, and in the stars; and upon the earth distress of nations, with perplexity; the sea and the waves roaring; (Luke 21:25)
… Men’s hearts failing them for fear, and for looking after those things which are coming on the earth: for the powers of heaven shall be shaken; (Luke 21:26)
… This know also, that in the last days perilous times shall come. (2 Timothy 3:1)
Jesus is giving a series of prophecies about what to look for as the age of grace comes to a close. These verses are several of many such prophecies from throughout the Bible. 2017 was the worst year in recorded history for the intensity, frequency, severity, duration and occurrence of a large number of severe natural disasters worldwide. Earthquakes, volcanoes, hurricanes, typhoons, cyclones, torrential flooding, unprecedented wildfires in unusual places, devastating droughts, excessive/scorching heat setting records everywhere, record snowfalls in Europe and Russia. Snow in the Arabia. This list can go on. Most studied Eschatologists believe these ‘fearful sights’ and massive natural disasters are all part of the ‘CONVERGENCE’ of signs that this Biblical and prophetic age is closing. Most people who study prophecy are familiar with the routine reference(s) made that these things will be like a woman having labor pains, growing in intensity, frequency, size and duration.

Study: Malaria Drugs Are Failing At An ‘Alarming’ Rate In Southeast Asia

July 22, 20196:31 PM  JASON BEAUBIEN NPR

Malaria drugs are failing at an “alarming” rate in Southeast Asia as drug-resistant strains of the malaria parasite emerge.

That’s the conclusion of researchers in two new reports — one based on a randomized trial and the other on a genetic study — that have just been released in the medical journal The Lancet. And there’s concern that this drug resistance could spread around the globe.

Global health officials get nervous when new strains of drug-resistant malaria turn up in Southeast Asia, because it’s a dreaded pattern that they’ve seen before.

Resistance that has hatched in this region has doomed previous malaria medications since the middle of the 20th century.

“Somehow antimalarial drug resistance always starts in that part of the world,” says Arjen Dondorp, who leads malaria research at the Mahidol Oxford Tropical Medicine Research Unit in Bangkok and who was a lead author of the report about the randomized trial.

“In the past, chloroquine resistance originated there. Sulfadoxine-pyrimethamine, the next generation of antimalarials — resistance to that originated there. And now the artemisinin resistance also was first detected in western Cambodia.”

And it’s hard to underscore the significance of this. In modern times, the death spiral for malaria drug after malaria drug has begun in the Mekong Delta. The reasons for this are complicated. Some scientists say that one reason could have something to do with the relatively low levels of malaria there. When resistant parasites emerge, they are not competing against a dominant nonresistant strain of malaria and are possibly able to spread easier.

Currently, the World Health Organization recommends treating the majority of malaria cases with artemisinin-based combination therapies, or ACTs. These are usually single pills that combine fast-acting artemisinin with another longer-acting antimalarial drug. Currently one of the most widely used ACTs globally is dihydroartemisinin-piperaquine. And this is the artemisinin combo that Dondorp found to be failing in Southeast Asia.

These drugs have been highly effective at treating malaria, one of the world’s most burdensome diseases. According to the World Health Organization, each year there are more than 200 million cases of malaria and 400,000 people die from the disease. Those deaths are primarily among children in Africa.

The two-drug artemisinin combos continue to be the first-line drugs for treating most malaria cases around the world, including in Africa. And they have been credited with helping to bring global malaria deaths down to an all-time low. But now it looks like their future effectiveness is in question.

Dondorp, in the midst of a study in the greater Mekong region, was comparing a new three-drug malaria regimen against the conventional two-drug artemisinin combo. And it was in the middle of that study that he and his colleagues saw that the current antimalarial drugs weren’t fully wiping out the potentially deadly parasites.

“We noticed incredible high failure rates with the first-line treatment, and that was the reason to publish this first before we can publish the results of the efficacy of the triple combinations,” he says. Basically, the current drugs were performing so badly that the researchers felt it imperative to sound the alarm about what was the control side of the study.

The overall failure rate was 50%. But in some parts of the region, the drugs weren’t working nine times out of 10.

Dondorp says the resistance was even worse than they’d expected.

“We knew already [resistance] was in Cambodia and it had increased dramatically over the years,” he says. “What was new was that it was also present in northeastern Thailand and southern Vietnam.”

Health officials in Cambodia were aware that the drugs were failing and had switched back to an older medicine in 2014. Now Vietnam and Thailand are also moving away from the World Health Organization’s recommended first-line malaria treatment.

So far this drug resistance has been mainly found in the areas around the Mekong Delta, but there’s no reason these parasites couldn’t spread to India or other parts of Asia or even Africa.

That has been the case with every other first-line malaria drug. If a person who was infected with chloroquine-resistant parasites, say in Cambodia, traveled to India and got bitten by mosquitoes there, the resistant parasites could start spreading in India. Then someone else in India could carry the parasites to Kenya. Soon, the chloroquine-resistant malaria bugs would have gone global.

And if that happens with the latest line of artemisinin combination treatments, it could be a major setback to global efforts to control the mosquito-borne disease.

“It is really worrying,” says Shunmay Yeung, an associate professor at the London School of Hygiene & Tropical Medicine. Yeung studies malaria and malaria drug resistance, though she wasn’t involved in these new studies in The Lancet. She says there has been incredible progress against malaria over the past 15 years. “We’ve halved the number of deaths due to malaria globally,” she says.

And artemisinin-based antimalarials, along with increased distribution of mosquito bed nets, have been a major force in achieving that. They are “wonderfully effective drugs,” she says.

“It’s three days of treatment and you’re better.” They work quickly. They have few side effects. “To lose these first-line drugs, the artemisinin combination therapies, would be disastrous,” Yeung says. “If this [resistance] emerged or spread to Africa, it would be a disaster.”

Globally the majority of malaria cases occur in Africa.

So far, however, the mutant malaria parasites that have built up a resistance to artemisinin-based drugs haven’t taken hold on the continent.

But if the histories of other antimalarial drugs are any guide to the future, they eventually will.

Pestilence

Disease

Death

Virus

Bacteria

Superbugs

Contagion

Epidemic

Pandemic

Spreading from one person to another

Perilous times have come

Pestilence spreading around the world

Pestilence in diverse places

Disease spreading around the world

Disease in diverse places

Disease increasing in frequency

Disease increasing in size

Disease increasing in strength

Disease increasing in duration

Increasing like the pains of a woman in labor