Genetic Manipulation and Hybridization Update

The future of genetic enhancement is not in the West (2016). Foreshadowing the rise of genetic manipulation in China (2018).

Blog note: As in the days of Noah. End of note.

Blog note: The science of genetic engineering is steadily marching forward. Once the “Restrainer” (Holy Spirit) no longer restrains the evil one, there will no longer be any ethical or moral restraint in the use of this technology. The technology is not evil. It is the hand that violates the genetic code in the pursuit of genetic corruption of the imagers of God. Studied Eschatologists understand the implication of this. “In the days of Noah” God indicates that all flesh on earth (both mankind and animals) had become “corrupted”. Noah was the only one whose genetics had not become “corrupted” and was found “perfect in his generation.” The evil of lawlessness and genetic manipulation was so great that God cleaned the earth’s slate with the Great Flood. It was that bad. Yet, here we are again today. In the name of science, research and ending diseases, we search to find ways to manipulate genetics. There are two arguments; that it is good to try to find cures to diseases that result from genetic flaws. Others argue that we should not be playing “God” and messing with what God has designed. I agree strongly in favor of the “we should not be playing God” side. My concern is, that no matter how noble or well-intentioned the pursuit of genetics to solve diseases is, it will ultimately become a bastardized abomination of corruption. I’ll say it again, once the “Restrainer” (Holy Spirit) is gone, there will NOT be any moral, ethical or spiritual restraints or constraints on the evil use of genetic manipulation techniques. There will be educated, scientific people who will mock my discernment of this issue by arguing this “would never happen on their watch.” What if their life or family member’s lives were threatened if they did not work on human genetic manipulation projects? Who would possibly threaten them? and why? What could the consequences be from un-naturally manipulating the human genome? I am not a genetic scientist (although I am a data scientist). The potential genetic abominations could only be abhorrent. God seems to think so since he had to wipe the earth clean once before. End of note.

… And Knowledge shall increase (grow).

… As in the days of Noah. All flesh had become corrupted. Noah was perfect in his generations. 

The future of genetic enhancement is not in the West (2016). Foreshadowing the rise of genetic manipulation in China (2018).

Theconversation.com. 2016

Would you want to alter your future children’s genes to make them smarter, stronger or better-looking? As the state of the science brings prospects like these closer to reality, an international debate has been raging over the ethics of enhancing human capacities with biotechnologies such as so-called smart pills, brain implants and gene editing. This discussion has only intensified in the past year with the advent of the CRISPR-cas9 gene editing tool, which raises the specter of tinkering with our DNA to improve traits like intelligence, athleticism and even moral reasoning.

So are we on the brink of a brave new world of genetically enhanced humanity? Perhaps. And there’s an interesting wrinkle: It’s reasonable to believe that any seismic shift toward genetic enhancement will not be centered in Western countries like the U.S. or the U.K., where many modern technologies are pioneered. Instead, genetic enhancement is more likely to emerge out of China.

Attitudes toward enhancement

Numerous surveys among Western populations have found significant opposition to many forms of human enhancement. For example, a recent Pew study of 4,726 Americans found that most would not want to use a brain chip to improve their memory, and a plurality view such interventions as morally unacceptable.

broader review of public opinion studies found significant opposition in countries like Germany, the U.S. and the U.K. to selecting the best embryos for implantation based on nonmedical traits like appearance or intelligence. There is even less support for editing genes directly to improve traits in so-called designer babies.

Opposition to enhancement, especially genetic enhancement, has several sources. The above-mentioned Pew poll found that safety is a big concern – in line with experts who say that tinkering with the human genome carries significant risks. These risks may be accepted when treating medical conditions, but less so for enhancing nonmedical traits like intelligence and appearance. At the same time, ethical objections often arise. Scientists can be seen as “playing God” and tampering with nature. There are also worries about inequality, creating a new generation of enhanced individuals who are heavily advantaged over others. “Brave New World” is a dystopia, after all.

However, those studies have focused on Western attitudes. There has been much less polling in non-Western countries. There is some evidence that in Japan there is similar opposition to enhancement as in the West. Other countries, such as China and India, are more positive toward enhancement. In China, this may be linked to more generally approving attitudes toward old-fashioned eugenics programs such as selective abortion of fetuses with severe genetic disorders, though more research is needed to fully explain the difference. This has led Darryl Macer of the Eubios Ethics Institute to posit that Asia will be at the forefront of expansion of human enhancement.

Restrictions on gene editing

In the meantime, the biggest barrier to genetic enhancement will be broader statutes banning gene editing. A recent study found bans on germline genetic modification – that is, those that are passed on to descendants – are in effect throughout Europe, Canada and Australia. China, India and other non-Western countries, however, have laxer regulatory regimes – restrictions, if they exist, are often in the form of guidelines rather than statutes.

The U.S. may appear to be an exception to this trend. It lacks legal restriction of gene editing; however, federal funding of germline gene editing research is prohibited. Because most geneticists rely on government grants for their research, this acts as a significant restriction on germline editing studies.

By contrast, it was Chinese government funding that led China to be the first to edit the genes of human embryos using the CRISPR-cas9 tool in 2015. China has also been leading the way in using CRISPR-cas9 for non-germline genetic modifications of human tissue cells for use in treatment of cancer patients.

There are, then, two primary factors contributing to emergence of genetic enhancement technologies – research to develop the technologies and popular opinion to support their deployment. In both areas, Western countries are well behind China.

What makes China a probable petri dish

A further, more political factor may be at play. Western democracies are, by design, sensitive to popular opinion. Elected politicians will be less likely to fund controversial projects, and more likely to restrict them. By contrast, countries like China that lack direct democratic systems are thereby less sensitive to opinion, and officials can play an outsize role in shaping public opinion to align with government priorities. This would include residual opposition to human enhancement, even if it were present. International norms are arguably emerging against genetic enhancement, but in other arenas China has proven willing to reject international norms in order to promote its own interests.

Indeed, if we set ethical and safety objections aside, genetic enhancement has the potential to bring about significant national advantages. Even marginal increases in intelligence via gene editing could have significant effects on a nation’s economic growth. Certain genes could give some athletes an edge in intense international competitions. Other genes may have an effect on violent tendencies, suggesting genetic engineering could reduce crime rates.

Many of these potential benefits of enhancement are speculative, but as research advances they may move into the realm of reality. If further studies bear out the reliability of gene editing in improving such traits, China is well-poised to become a leader in the area of human enhancement.

Does this matter?

Aside from a preoccupation with being the best in everything, is there reason for Westerners to be concerned by the likelihood that genetic enhancement is apt to emerge out of China?

If the critics are correct that human enhancement is unethical, dangerous or both, then yes, emergence in China would be worrying. From this critical perspective, the Chinese people would be subject to an unethical and dangerous intervention – a cause for international concern. Given China’s human rights record in other areas, it is questionable whether international pressure would have much effect. In turn, enhancement of its population may make China more competitive on the world stage. An unenviable dilemma for opponents of enhancement could emerge – fail to enhance and fall behind, or enhance and suffer the moral and physical consequences.

Conversely, if one believes that human enhancement is actually desirable, this trend should be welcomed. As Western governments hem and haw, delaying development of potentially great advances for humanity, China leads the way forward. Their increased competitiveness, in turn, would pressure Western countries to relax restrictions and thereby allow humanity as a whole to progress – becoming healthier, more productive and generally capable.

Either way, this trend is an important development. We will see if it is sustained – public opinion in the U.S. and other countries could shift, or funding could dry up in China. But for now, it appears that China holds the future of genetic enhancement in its hands.

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