Genetic Manipulation and Hybridization Update

Genome. Now We Can 3D Map It. The more we learn about the structure of the human genome, the better equipped we’ll be to eventually write a genome of our own.

Blog note: The science of genetic engineering is steadily marching forward. Once the “Restrainer” (Holy Spirit) no longer restrains the evil one, there will no longer be any ethical or moral restraint in the use of this technology. The technology is not evil. It is the hand that violates the genetic code in the pursuit of genetic corruption of the imagers of God. Studied eschatologists understand the implication of this. “In the days of Noah” God indicates that all flesh on earth (both mankind and animals) had become “corrupted”. Noah was the only one whose genetics had not become “corrupted” and was found “perfect in his generation.” The evil of lawlessness and genetic manipulation was so great that God cleaned the earth’s slate with the Great Flood. It was that bad. Yet, here we are again today. In the name of science, research and ending diseases, we search to find ways to manipulate genetics. There are two arguments, that it is good to try to find cures to diseases that result from genetic flaws. Others argue that we should not be playing “God” and messing with what God has designed. I agree strongly in favor of the “we should not be playing God” side. My concern is, that no matter how noble or well intentioned the pursuit of genetics to solve diseases is, it will ultimately become a bastardized abomination of corruption. I’ll say it again, once the “Restrainer” (Holy Spirit) is gone, there will NOT be any moral, ethical or spiritual restraints or constraints on the evil use of genetic manipulation techniques. There will be educated, scientific people who will mock my discernment of this issue by arguing this “would never happen on their watch.” What if their life or family member’s lives were threatened if they did not work on human genetic manipulation projects? Who would possibly threaten them? and why? What could the real world consequences be from un-naturally manipulating the humane genome? I am not a genetic scientist (although I am a data scientist). The potential genetic abominations could only be abhorrent. God seems to think so since he had to wipe the earth clean once before. End of note.

Genome. Now We Can 3D Map It. The more we learn about the structure of the human genome, the better equipped we’ll be to eventually write a genome of our own.

Kristin Houser August 28, 2018.

THE NEXT STEP. In 2003, researchers sequenced the human genome for the first time, writing out all 3 billion of the DNA base pairs that dictate every aspect of our makeup. Now, a new team of researchers has figured out a way to create a 3D image of this valuable roadmap to human biology.

They published their research on Tuesday in the Journal of Cell Biology.

A BETTER MAP. After we sequenced the human genome, we had a (very) long list of letters. We knew about the double helix, and that every human cell contained this entire sequence of DNA in more or less this particular order, but we didn’t know much about the three-dimensional location of the DNA pairs — that is, where the various pairs in the double helix were located in relationship to the cell’s nuclear structures. That’s important, because it can tell us a lot about their function and activity

That’s where this new study from the University of Illinois at Urbana-Champaign comes into play.

Those researchers developed a mapping technique they call tyramide signal amplification sequencing (TSA-Seq). Tyramide is a molecule that, once it’s released from a special enzyme placed around particular nuclear structures, tags any DNA it happens to be around. The closer a gene is to those particular structures, the stronger the signal from the tyramide label — the same way your clothes get more damp if you’re standing closer to a sprinkler.

LOCATION, LOCATION, LOCATION. The researchers tested TSA-Seq in leukemia cells in the lab (don’t worry, the cells weren’t alive). They figured out that genes closer to one kind of nuclear structure (nuclear speckles) were often more active than those closer to another (nuclear lamina).

We don’t actually know what nuclear speckles do, but we might be better equipped to figure that out now that we know they seem to play some sort of role in genetic activity.

“The logic of this nuclear organization remains to be determined, but our model would suggest that chromosome movements of just a few hundred nanometers could have substantial functional significance,” researcher Andrew Belmont said in a news release.

For now, the team plans to continue developing its TSA-Seq technique. Eventually, the researchers hope to map the 3D positions of genes in other types of cells, focusing on how the positions might change as the cells age or become diseased. The more we learn about the structure of the human genome, the better equipped we’ll be to eventually write a genome of our own.

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