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The New Normal, Genetic Corruption Just in Time for Halloween 2020; Fast, cheap, accurate: Researchers pin hopes on Nobel Prize-winning CRISPR technology to detect coronavirus

‘As in the days of Noah.’ – Genetic Corruption of Flesh

Matthew 24:37 But as the days of Noah were, so shall also the coming of the Son of man be.

Genesis 6:9, 11, 12 These are the generations of Noah: Noah was a just man and perfect in his generations, and Noah walked with God. The earth also was corrupt before God, and the earth was filled with violence. And God looked upon the earth, and, behold, it was corrupt; for all flesh had corrupted his way upon the earth.

Genesis 7:1-4  And the Lord said unto Noah, Come thou and all thy house into the ark; for thee have I seen righteous before me in this generation. Of every clean beast thou shalt take to thee by sevens, the male and his female: and of beasts that are not clean by two, the male and his female. Of fowls also of the air by sevens, the male and the female; to keep seed alive upon the face of all the earth. For yet seven days, and I will cause it to rain upon the earth forty days and forty nights; and every living substance that I have made will I destroy from off the face of the earth.

Saudi Arabia – Mohammed bin Salman – NEOM; There will also be gene-editing facilities that will be used to make humans stronger and smarter than ever before, according to the WSJ.

The New Normal, Genetic Corruption Just in Time for Halloween 2020; Fast, cheap, accurate: Researchers pin hopes on Nobel Prize-winning CRISPR technology to detect coronavirus

Ken Alltucker USA TODAY October 25, 2020

https://www.usatoday.com/videos/news/nation/2020/10/07/crispr-explained-how-gene-editing-tool-works/5909992002/

Coronavirus tests performed in labs are the gold standard for accuracy, and antigen tests are a fast and inexpensive alternative.

But backers of a third type of test, developed by a Nobel Prize winner using cutting-edge CRISPR technology, say it has the potential to be all three: rapid, accurate and inexpensive.

Although these gene-editing technology tests are still being developed and won’t be ready in the United States this year as the weather cools and demand surges, research groups recently published papers describing them as an appealing alternative as testing shortages persist amid the COVID-19 pandemic. 

Dr. Jennifer Doudna, a University of California-Berkeley researcher whose pioneering work in CRISPR earned a share of this year’s Nobel Prize in chemistry, said the test can be done quickly and doesn’t require a lab. 

“We have a ways to go before CRISPR-based diagnostics reach widespread use, but I believe we’ll see an impact during the current pandemic,” Doudna said. “Because it is simple to adjust these tests to detect other targets, the platform we’re developing now is laying the groundwork to deploy CRISPR for rapid diagnosis during future outbreaks.”

CRISPR, or clustered regularly interspaced short palindromic repeats, is a gene-editing technology studied for a wide range of uses from cancer and sickle cell disease treatments to improved food production.

In 2016, Doudna’s lab developed a way to detect RNA using the technology. Her lab collaborated with Dr. Melanie Ott of San Francisco-based Gladstone Institutes to  develop an HIV test, but when the pandemic hit, the researchers focused on developing a coronavirus test.

The test recognizes a sequence of RNA in SARS-CoV-2, the coronavirus that causes COVID-19. 

In an Oct. 12 publication, researchers reported the test yielded results in five minutes and correctly identified five samples from patients with the coronavirus. When used with a mobile phone to detect signals generated by the test, the technology could provide a fast, low-cost test outside a laboratory, researchers saidin the paper, which was not peer-reviewed. 

Massachusetts Institute of Technology scientists also are honing a CRISPR-based test that can be used outside a lab. In a New England Journal of Medicine letter published last month, researchers said the test was evaluated at a University of Washington lab using 202 samples with the coronavirus and 200 without. The test correctly identified 93.1% of positive samples. The test also had 98.5% specificity, which means it rarely reported false positives.

Feluda, a paper-based CRISPR test named after a fictional India detective, has been cleared by that nation’s drug regulators for commercial launch. But it’s unclear how the Indian conglomerate Tata Group plans to deploy the test in India, which trails only the United States with nearly 7.7 million cases, according to data from Johns Hopkins University. 

Testing that is fast and accurate 

Gigi Gronvall, a senior scholar at the Johns Hopkins Center for Health Security, said she expects more labs will explore tests using this technology. She called it “extremely promising” because people can use the tests outside the lab

“That has been a big challenge with testing generally,” Gronvall said. “People need to have their results pretty quickly otherwise they keep going about their day and they might be infectious and not stop having contact with other people.”

The south San Francisco-based biotechnology firm Mammoth Biosciences, co-founded by Doudna, is working to further develop its test and make it available to labs and medical providers. The company received a National Institutes of Health grant to accelerate development.

Mammoth CEO Trevor Martin said the company’s goal is to make a test that is fast and accurate.

“Right now you have to make this choice: Do you want something that is simple and fast or something that has the highest accuracy?” Martin said.

The most accurate lab tests are molecular-based polymerase chain reaction, or PCR, which amplify a small amount of genetic material from a nasal swab sample. Labs are limited in the number of PCR tests they can run because of periodic shortages of chemical reagents and other testing materials. In July, when demand outpaced labs’ ability to perform tests, consumers whose tests were routed to major labs routinely waited a week or longer for results.

Antigen tests, which detect proteins of the coronavirus, can produce results in 15 minutes but are considered less sensitive than lab tests. 

Martin said CRISPR-based tests offer “a technology that is very simple, very fast yet extremely accurate.”

Scaling up to be cheap and accessible

Beyond the technology, test developers are trying to solve another challenge: designing a test that is easy to use and inexpensive.

Dr. Feng Zhang, an MIT biochemist and core member of the Broad Institute whose lab is developing the StopCOVID test, said his team wants to make a low-cost device that can work with a disposable cartridge. Collaborators want a test easy enough for consumers to use at home by taking their own nasal swab.

“The challenge is to work out how to scale up the manufacturing so that we can get the cost to be as low as possible,” Zhang said. 

He said his collaborators are working to bring the test to market as soon as possible. A version of the test already is being used by a Thailand hospital to screen patients.

Mammoth’s Martin said designing a test for wide use is “where a lot of things stumble.”

“It’s really nice to have a new technology but you need to get it to the places where it’s needed,” he said. “That’s something we’ve been working on very diligently.” 

Dr. Sophia L. Yohe, director of the University of Minnesota’s Molecular Diagnostics Laboratory, said it’s unknown whether test developers will be able to streamline steps to allow a large number of tests.

Some early versions of CRISPR tests required samples to be extracted and amplified, similar to a lab-based PCR tests, said Yohe, chair of the College of American Pathologists Personalized Health Care Committee.  

“If you can do only one test at a time, even if it only takes 30 minutes, suddenly doing a thousand tests takes a long time,” she said. “So scalability I think is an issue that has to be considered if you are looking at doing high volumes of testing

Night Watchman Note; We are to ‘be watchful’ in helping to understand today’s events as related to biblical prophecy. That is what ‘watchmen or women’ do. Jesus made clear that when He actually does come for His disciples, His wise and faithful servants would be aware of the time because they would be watching. They would know the season of the times by WATCHING those things ‘coming to pass or occurring’ as Jesus said they would. The ‘BENCHMARK SIGN(s)’ always point towards Israel / Jacob. God’s prophetic timepiece. The FALSE PEACE COVENANT confirmed by the Prince/Beast among MENA (the many) is the ‘key sign’ of the times or the season of the times. Yes, we are in that period. The Prince/Beast will likely confirm and enhance the current ‘normalization’ agreement with Jacob to be a ‘peace’ agreement, to be extended to 7 years from the current 5 years, to include some agreement permitting the rebuilding of the third temple in exchange for ‘some portion of Jerusalem.’ The current ‘investment’ period for the Palestinians stands at five (5) years. This will likely occur AFTER the Bride, Disciples or True Church is removed from the earth via the Rapture / Harpazo / Redemption / ‘Twinkling’.

Seven (7) References to ‘BE WATCHING or WATCHFUL.’

Matthew 24:42; Watch therefore: for ye know not what hour your Lord doth come.

Matthew 25:13; Watch therefore, for ye know neither the day nor the hour wherein the Son of man cometh.

Mark 13:35; Watch ye therefore: for ye know not when the master of the house cometh, at even, or at midnight, or at the cockcrowing, or in the morning.

Luke 21:36; Watch ye therefore, and pray always, that ye may be accounted worthy to escape all these things that shall come to pass, and to stand before the Son of man

Luke 12:37-39; Blessed are those servants, whom the lord when he cometh shall find watching: verily I say unto you, that he shall gird himself, and make them to sit down to meat, and will come forth and serve them.And if he shall come in the second watch, or come in the third watch, and find them so, blessed are those servants.And this know, that if the goodman of the house had known what hour the thief would come, he would have watched, and not have suffered his house to be broken through.

1 Thessalonians 5:2-4; For yourselves know perfectly that the day of the Lord so cometh as a thief in the night. For when they shall say, Peace and safety; then sudden destruction cometh upon them, as travail upon a woman with child; and they shall not escape. But ye, brethren, are not in darkness, that that day should overtake you as a thief. (Be Watching).

John 13:19 Now I tell you before it come, that, when it is come to pass, ye may believe that I am he.

John 14:29 And now I have told you before it come to pass, that, when it is come to pass, ye might believe.

Luke 21:31 So likewise ye, when ye see these things come to pass, know ye that the kingdom of God is nigh at hand.

Mark 13:29 So ye in like manner, when ye shall see these things come to pass, know that it is nigh, even at the doors.

Luke 21:28 And when these things begin to come to pass, then look up, and lift up your heads; for your redemption draweth nigh.

Revelation 1:1 The Revelation of Jesus Christ, which God gave unto him, to shew unto his servants things which must shortly come to pass; and he sent and signified it by his angel unto his servant John:

‘Increasing Like Labor Pains.’ ‘Fearful Sights.’ ‘Perilous Times.’ ‘Men’s hearts failing with fear.’ Great Convergence of Signs.’ REDEMPTION IMMINENT.

In His Service,

Night Watchman

Paul Rolland

Night Watchman Ministries

Make Your Decision for Christ NOW!!!!!!! Time is Up!!!!!!!

Jesus Christ’s Offer of Salvation:

The ABCs of Salvation through Jesus Christ (the Lamb)

A. Admit/Acknowledge/Accept that you are sinner. Ask God’s forgiveness and repent of your sins.

. . . “For all have sinned, and come short of the glory of God.” (Romans 3:23).

. . . “As it is written, There is none righteous, no, not one.” (Romans 3:10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us.” (1 John 1:8).

B. Believe Jesus is Lord. Believe that Jesus Christ is who He claimed to be; that He was both fully God and fully man and that we are saved through His death, burial, and resurrection. Put your trust in Him as your only hope of salvation. Become a son or daughter of God by receiving Christ.

. . . “That whosoever believeth in him should not perish, but have eternal life. For God so loved the world, that he gave his only begotten Son, that whosoever believeth in him should not perish, but have everlasting life. For God sent not his son into the world to condemn the world; but that the world through him might be saved. (John 3:15-17). For whosoever shall call upon the name of the Lord shall be saved.” (Romans 10:13).

C. Call upon His name, Confess with your heart and with your lips that Jesus is your Lord and Savior.

. . . “That if thou shalt confess with thy mouth the Lord Jesus, and shalt believe in thine heart that God hath raised him from the dead, thou shalt be saved. For with the heart man believeth unto righteousness; and with the mouth confession is made unto salvation.” (Romans 10:9-10).

. . . “If we say that we have no sin, we deceive ourselves, and the truth is not in us. If we confess our sins, he is faithful and just to forgive us our sins, and to cleanse us from all unrighteousness. If we say that we have not sinned, we make him a liar, and his word is not in us.” (John 1:8-10).

. . . “And he is the propitiation for our sins: and not for ours only, but also for the sins of the whole world. (John 2:2).

. . . “In this was manifested the love of god toward us, because that God sent his only begotten Son into the world, that we might live through him. And we have seen and do testify that the Father sent the Son to be the Saviour of the world. Whosoever shall confess that Jesus is the Son of God, God dwelleth in him, and he in God.” (1 John 4:9, 14-15).

. . . “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.” (Romans 5:8-10).

. . . “For the wages of sin is death; but the gift of God is eternal life through Jesus Christ our Lord.” (Romans 6:23).

. . . “Jesus saith unto them, I am the way, the truth, and the life, no man cometh unto the Father, but by me.” (John 14:6).

. . . “For I am not ashamed of the gospel of Christ: for it is the power of God unto salvation to everyone that believeth.” (Romans 1:16).

. . . “Neither is there salvation in any other: for there is none other name under heaven given among men, whereby we must be saved.” (Acts: 4:12).

. . . “Who will have all men to be saved, and to come unto the knowledge of the truth for there is one God, and one mediator between God and men, the man Christ Jesus.” (1 Timothy 2:4-6).

. . . “For God did not appoint us to suffer wrath but to receive salvation through our Lord Jesus Christ.” (1 Thessalonians 5:9).

. . . “But as many as received him, to them gave the power to become the sons of God, even to them that believe on his name.” (John 1:12).

True Church / Bride of Christ Spared from God’s Wrath:

 Romans 5:8-10. “But God commendeth his love toward us, in that, while we were yet sinners, Christ died for us. Much more then, being now justified by his blood, we shall be saved from wrath through him. For if, when we were enemies, we were reconciled to God by the death of his Son, much more, being reconciled, we shall be saved by his life.”

Romans 12:19Dearly beloved, avenge not yourselves, but rather give place unto wrath: for it is written, Vengeance is mine; I will repay, saith the Lord.

1 Thessalonians 1:10. And to wait for his Son from heaven, whom he raised from the dead, even Jesus, which delivered us from the wrath to come.

1 Thessalonians 5:9. For God hath not appointed us to wrath, but to obtain salvation by our Lord Jesus Christ,

Romans 8:35. Who shall separate us from the love of Christ? shall tribulation, or distress, or persecution, or famine, or nakedness, or peril, or sword?

Jeremiah 30:7. Alas! for that day is great, so that none is like it: it is even the time of Jacob’s trouble, but he shall be saved out of it.

Revelation 3:10 Because thou hast kept the word of my patience, I also will keep thee from the hour of temptation, which shall come upon all the world, to try them that dwell upon the earth.

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